Pathology
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Fetopathology and developmental pathology of the embryo and fetus
Marta Ježová, Josef Feit et al.
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Gestational trophoblastic disease (GTD)
Introduction

Group of disorders which are associated with pregnancy and arise from abnormal growth of placental trophoblast.

They occur in women in reproductive age.

The common feature of these disorders is that they produce hCG (chorionic gonadotropin), which is a useful marker for diagnostics, evaluation of the clinical course and response to therapy.

Both benign nonneoplastic disorders (hydatidiform mole) and malignant aggresive neoplasms (choriocarcinoma) are included.

Classification
  • Nonneoplastic disorders (tumor — like masses resembling placenta)
    • Hydatidiform mole
  • Neoplams:
    • Choriocarcinoma
    • Placental site trophoblastic tumor and epithelioid trophoblastic tumor  —  both are very rare