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Fetopathology and developmental pathology of the embryo and fetus
Marta Ježová, Josef Feit et al.
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Invasive mola (mole proliferans, mole destruens)
Introduction

Complete or partial mole characterized by aggresive tumor — like behaviour.

In spite of this behaviour invasive mole is not a neoplasm.

Clinical signs
  • chorionic villi are found within myometrium or vascular spaces
  • molar villi may embolize to the lung, vagina or brain (so called metastatic mole); these emboli are not real metastases because they undergo regression and do not form a secondary focus
  • hCG titres are high
  • therapy: invasive mole is managed by chemotherapy
Histology

The diagnosis of invasive mole can be confirmed only when surgical resection is examined. Surgery is not a standard procedure. That is why treatment is usually applied without definitive pathologic confirmation.