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Fetopathology and developmental pathology of the embryo and fetus
Marta Ježová, Josef Feit et al.
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Placental site trophoblastic tumor
Introduction

Rare tumor derived from intermediate trophoblast of implantation site (not from villous trophoblast as choriocarcinoma).

Clinical signs
  • women in reproductive years
  • abnormal bleeding resembling spontaneous abortion is a common clinical presentation
  • hCG titers are generally low (in contrast to choriocarcinoma)
  • prognosis:
    • usually benign
    • 15% of reported cases show aggresive behaviour with disseminated metastases
Histology
  • monomorphic pattern: intermediate trophoblastic cells, fibrinoid, necrosis
  • tumor cells extensively infiltrate the endometrium and myometrium