Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Lupus erythematodes, subacute
Clinical signs
  • locations: areas of insolation, symmetric exanthema of the dorsal parts of the extremities
  • red, annular, multiform or papulosquamous lesions
  • severe photosensitivity
  • systemic lesions are mild: CNS, joints, kidneys
  • associated with Sjögren's syndrome
Pictures

Annular lesions of the subacute lupus erythematosus: Lupus erythematodes, subacute, Clinical picture (1078)

SCLE, subacute lupus erythematosus of the skin: Lupus erythematodes, subacute, Clinical picture (1079)

Histology

Vacuolar degeneration of the basal layer; perivascular and periadnexal lymphocytic infiltrate; fibrosis; sometimes vasculitis.

Immunofluorescence: deposits of various kinds of immunocomplexes and C3 along dermo-epidermal junction (the deposits are present in clinically uninvolved skin as well). Direct immunofluorescence sometimes show anti-Ro and anti-La antibodies between the cells of the basal layer (SLE, subacute LE, Sjögren's syndrome).