Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Acute neonatal lupus erythematodes
Clinical signs

Affects newborns (more often girls), whose mothers have Ro/SSA antibodies. The symptoms are not visible after the delivery, but appear during the first weeks of life.

  • rare
  • affects 1% of mothers with lupus erythematosus
  • affects the skin, kidneys, liver
  • systemic lupus erythematosus in mother may appear later
  • skin lesions dissappear, but damage of the heart may be permanent (arrythmia)
Etiology

IgG antibodies against Ro (SSA) a La (SSB) pass through the placenta and may cause lupus erythematosus in the child. Similar condition may occurr in other autoimmune diseases (Sjögren's syndrome, rheumatoid arthritis).

Histology

Histological picture correspond to acute lupus erythematosus.

Pictures

Lupus erythematodes of a newborn. In this case the diagnosis was not evident at first, the child has received blood transfusions and there was suspition of sepsis with circulating immature white blood and red blood cells. Immunohistological reaction to myoglobin was negative, immature white blood cells were shown by myeloperoxidase reaction. The basal membrane of the epidermis focally damaged and the amount of mucin in the corium was slightly increased. The mother had increased levels of serum antibodies: Lupus erythematodes, acute, congenital, HE 60x (6277) Lupus erythematodes, acute, congenital, PAS 60x (6280) Lupus erythematodes, acute, congenital, alcian blue 60x (6274) Lupus erythematodes, acute, congenital, Halle 60x (6276) Lupus erythematodes, acute, congenital, myeloperoxidase 60x (6279) Lupus erythematodes, acute, congenital, hemoglobin 60x (6278) Lupus erythematodes, acute, congenital, CD20 60x (6275)