Pathology
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Fetopathology and developmental pathology of the embryo and fetus
Marta Ježová, Josef Feit et al.
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Pseudohermaphroditism masculinus
Clinical signs
  • 46XY, testis
  • external: female genitalia, ambiguous genitalia
Etiology, pathogenesis

Absent or insufficient androgen effect on the target organs during the critical stage of the development can be caused by two mechanisms:

  • by disorder of testicular development, the testis regresses during the development and stops working (vanishing testis, dysgenetic testis)
  • by disorder of biosynthesis and androgen metabolism