Fetopathology and developmental pathology of the embryo and fetus: Androgen insensitivity syndrome, testicular feminization syndrome, female XY

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+ Androgen insensitivity syndrome, testicular feminization syndrome, female XY

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Androgen insensitivity syndrome, testicular feminization syndrome, female XY

Clinical signs

karyotype 46XY, 2 testes
inner genitalia: missing uterus, tubes, superior part of vagina and epididymis, ductus deferens, prostate
external genitalia: female, lower part of vagina is present

Etiology, pathogenesis

In target organs the androgen receptors are missing. Derivates of the Müllerian ducts disappear due to MIS, which is produced normally by the testes.