Pathology
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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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+ Bone Marrow Pathology
Refractory Anemia with Ringed Sideroblasts (RARS)
Clinical signs
  • basic features are the same as in RA
  • prognosis: about 1 – 2% of patients develop AML, median survival time is approx. 6 years
Histology
  • ringed sideroblasts constitute more than 15% of all erythroid precursors
  • ringed sideroblasts are erythroid precursors (normoblasts), siderotic granules are arranged in a ring around the nucleus
Pictures

Refractory anemia with ringed sideroblasts, iron stain: Refractory anemia with ring sideroblasts, Prussian blue 100x (72496)