Pathology
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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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+ Introduction
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+ Bone Marrow Pathology
Refractory Anemia with Excess Blats (RAEB)
Clinical signs
  • dysplastic changes are present in at least 10% of cells from two or more lineages
  • prognosis: 25% of patients with RAEB-1 and 33% of patients with RAEB-2 develop AML, median survival time is 18 (RAEB-1) or 10 (RAEB-2) months
Histology
  • the number of blasts in bone marrow is between 5 and 19%
  • RAEB-1: 5 – 9% myeloblasts
  • RAEB-2: 10 – 19% myeloblasts