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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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+ Bone Marrow Pathology
MDS with Isolated 5q Deletion (5q-syndrome)
Clinical signs
  • genetic definition: isolated deletion of the short arm of chromosome 5
  • less than 5% blasts in the bone marrow
  • middle-aged to elderly women
  • anemia, slight leukopenia, thrombocythemia
  • prognosis: relatively good
Histology

Dysplastic changes and increased numbers of small megakaryocytes with dysplastic hypolobated nuclei.

Pictures

MDS with isolated 5q deletion: 5q-syndrome, HE 100x (72892)