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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Prolymphocytic Leukemia (PLL)
Pathogenesis

The offending cell line is either the peripheral B (postgerminal) or T (post-thymic) cell (?).

Clinical signs
  • very rare disease, affecting mostly elderly patients (60 – 70 years old)
  • splenomegaly without lymphadenopathy
  • leukocytosis and lymphocytosis
  • anemia
  • thrombocytopenia
  • prognosis: not good, the disease often does not respond to therapy, median survival time is short (less than 1 year).
Histology

Prolymphocytes — middle-sized cells with round nuclei, dispersed chromatin, prominent nucleoli and a narrow rim of slightly basophilic cytoplasm.

Imunophenotype: B lineage (CD20 a CD79a+) nebo T lineage (CD3+), CD23-