Pathology
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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Chronic Lymphocytic Leukemia (CLL)
Pathogenesis

The offending cells are mature naive B lymphocytes.

Clinical signs
  • age: affects mostly elderly patients (median is approx. 65 years of age)
  • at first asymptomatic
  • anemia
  • thrombocytopenia
  • leukocytosis with lymphocytosis
  • hepatosplenomegaly
  • lymphadenopathy and other
  • prognosis:
    • low malignant disease
    • indolent progression
    • incurable
    • median survival time is 7 let
    • may transform into an agressive malignant lymphoma (Richter's syndrome)
Histology

Same as small lymphocytic lymphoma — small cells with the appearance of mature lymphocytes, with round nuclei, dense chromatin, and inconspicuous nucleoli, a narrow rim of basophilic cytoplasm. Proliferation centres also contain prolymphocytes and paraimunoblasts.

Imunophenotype: B lineage (CD20+ a CD79a+), CD5+, CD23+.

Pictures

Chronic lymphocytic leukemia, bone marrow: Chronic lymphatic leukemia, bone marrow, HE 100x (73238) Chronic lymphatic leukemia, bone marrow, PAS 100x (73239)

A different case: Chronic lymphatic leukemia B, HE 100x (73355) Chronic lymphatic leukemia B, PAS 100x (73356) Chronic lymphatic leukemia B, CD20 100x (73352) Chronic lymphatic leukemia B, CD5 100x (73354) Chronic lymphatic leukemia B, CD23 100x (73353)