Pathology
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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Acute Lymphoblastic Leukemia (ALL)
Pathogenesis

Caused by lymphoid precursors — lymphoblasts.

Clinical signs
  • age: most common in children, less common in adults
  • anemia
  • thrombocytopenia
  • leukopenia or leukocytosis
  • hepatosplenomegaly
  • lymphadenopathy
  • skin infiltration and other symptoms
  • prognosis: a very aggressive disease, which however has high cure rates, especially in children (70 – 80% of cases achieve complete remission)
Histology

Same as precursor lymphoblastic lymphoma —  small to middle-sized cells with round nuclei and finely dispersed chromatin, without prominent nucleoli, with a narrow rim of basophilic cytoplasm.

Imunophenotype: T lineage (CD3+) or B lineage (CD20+ a CD79a+), null type — both T and B markers are negative, CD10 (CALLA)+, TdT+.