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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Hairy cell leukemia (HCL)
Pathogenesis

Arises from postgerminal cells (?).

Clinical signs
  • age: usually affects middle-aged and older adults (median is approx. 55 years of age)
  • splenomegaly
  • bicytopenia or pancytopenia
  • prognosis: good, log-term remissions following chemotherapy or splenectomy
Histology

Intersticial infitration of the bone marrow, middle-sized cells with round or kidney-shaped nuclei with diffuse chromatin without nucleoli, abundant pale cytoplams with thin hair-like projections.

Imunophenotype: B lineage (CD20 a CD79a+), DBA44+, CD103+, TRAP+

Pictures

Hairy cell leukemia: Hairy cell leukemia, HE 100x (72411) Hairy cell leukemia, PAS 100x (72422) Hairy cell leukemia, CD20 100x (72410) Hairy cell leukemia, DBA44 100x (72421)