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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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+ Bone Marrow Pathology
Eosinophilic Granuloma
Clinical signs
  • relatively uncommon disease
  • age: children and adults
  • isolated bone lesions with osteolysis (different bones: ribs, femur heads etc.)
  • spontaneous bone pain in in the lesion location
  • brightened X-ray
  • pathological fractures may occur
  • prognosis is very good (following surgical scraping or radiation therapy sometimes even regress spontaneously)
Histology

The accumulation of Langerhans´s cells, eosinophils and additional plasma cells and neutrofils.

Immunophenotype: S100 protein, specifically CD1a; Birbeck´s granules may be observed using electron microscopy.