Pathology
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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Chronic Eosinophilic Leukemia (CEL)
Clinical signs
  • fever
  • fatigue
  • cough
  • angioedema
  • myalgia
  • pruritus, diarrhoea
  • sometimes neurological, pulmonar an rheumatic symptoms
Etiology

The BCR-ABL1 gene or the PDGFRA, PDGFRB rebuild is absent. JAK2 mutation is occasionally present.

Histology

Hypercellular bone marrow with predominatnt eosinophilic proliferation, the number of myeloblasts may be increased between 5 – 19%, Charcot-Leyden crystals are often present. Erythropoiesis and megakaryocytes are usually normal. Fibrosis may sometimes be found.