Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Necrobiosis lipoidica
Etiology, pathogenesis
  • unknown
  • most cases associated with diabetes
Clinical signs
  • often affected women with diabetes
  • ronud or oval multicolored (red, yellow) plaques on the shins, dorsa of the hands, sometimes forearms
  • chronic disease
Histology

Large areas of necrobiosis within the dermis, surrounded by palisading histiocytes, usually larger, deeper than in granuloma annulare; often multilayered.

Special staining reveal presence of fat droplets within the necrobiotic areas.

Another signs are epidermal atrophy, loss of elastic fibres within necrobiotic areas and dilatation of superficial blood vessels.

Pictures

Necrobiosis lipoidica: Necrobiosis lipoidica, HE 10x (328) Necrobiosis lipoidica, HE 20x (331) Necrobiosis lipoidica, HE 40x (334) Necrobiosis lipoidica, HE 40x (333)

Special stain for fat (oil red): Necrobiosis lipoidica, oil red 10x (329) Necrobiosis lipoidica, oil red 20x (332) Necrobiosis lipoidica, HE 40x (335)

Defect of elastic fibres in the necrobiotic area: Necrobiosis lipoidica, elastic fibres 5x (336) Necrobiosis lipoidica, elastic fibres 10x (327) Necrobiosis lipoidica, elastic fibres 20x (330)

Another case: Necrobiosis lipoidica, HE 10x (337)

Another case: Necrobiosis lipoidica, HE 5x (326) Necrobiosis lipoidica, elastic fibres 5x (325)

Another case: Necrobiosis lipoidica, HE 5x (578) Necrobiosis lipoidica, HE 20x (577) Necrobiosis lipoidica, HE 40x (579)

Another case: Necrobiosis lipoidica granulomatous, HE 5x (580) Necrobiosis lipoidica granulomatous, HE 20x (581) Necrobiosis lipoidica, oil red 10x (582) Necrobiosis lipoidica, oil red 40x (583)

Another case: Necrobiosis lipoidica, HE 60x (11003) Necrobiosis lipoidica, HE 20x (4868)

Another case: Necrobiosis lipoidica, HE 20x (4869)

Another case: Necrobiosis lipoidica, HE 60x (12097) Necrobiosis lipoidica, HE 20x (4870)

Another case: Necrobiosis lipoidica, HE 40x (12831)

Another case: Necrobiosis lipoidica, HE 40x (12832)

Another case: Necrobiosis lipoidica, HE 40x (12833)

Another case: Necrobiosis lipoidica, HE 60x (10792)

Another case: Necrobiosis lipoidica, HE 60x (13844) Necrobiosis lipoidica, elastic fibres 60x (13843)

Necrobiosis lipoidica, granulomatous: Necrobiosis lipoidica granulomatous, HE 60x (14061) Necrobiosis lipoidica granulomatous, x 60x (14060)

Necrobiosis lipoidica in postphlebectomic scar: Necrobiosis lipoidica in the scar post phlebectomy, HE 20x (4351) Necrobiosis lipoidica in the scar post phlebectomy, HE 20x (4349)