Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Rheumatoid nodule
Clinical signs
  • affect patients with rheumatid arthritis, typically od extensor surfaces
  • nodules several milimeters to several centimeters in size
  • patients have high levels of rheumatoid factor
  • pseudorheumatoid nodule is subcutaneous nodule, histologically similar, but in patients without rheumatoid arthritis, often in children.
Histology

Irregular, large areas of fibrinoid degeneration of collagen within dermis, surrounded by pallisading histiocytes.

Note: nodules in rheumatic fever are smaller, collagen degeneration is incomplete, neutrophils are present.