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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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+ Bone Marrow Pathology
Plasma Cell (Multiple) Myeloma
Introduction

Systemic bone marrow disease, with an occasional formation of osteolytic lesions.

Clinical signs
  • pathological bone fractures
  • anemia
  • hypercalcemia
  • monoclonal gammopathy (AL amyloidosis)
  • prognosis: bad, an incurable disease, median survival time is 3 years

Complex diagnostic criteria  — Durie-Salmon staging system.

Histology

The marrow is infiltrated with monoclonal plasma cells at various stages of differentiation (mature plasma cells, immature plasma cells, plasmablasts), with an occassional formation of osteolytic lesions.

Imunophenotype: CD138+, monoclonality according to the light chains of imunoglobulins kappa and lambda.

Pictures

Myeloma, bone marrow infiltration: Multiple myeloma, bone marrow, HE 100x (73120)

Myeloma, bone marrow infiltration: Myeloma, trephine biopsy, CD138 60x (74200) Myeloma, trephine biopsy, HE 60x (74201) Myeloma, trephine biopsy, HE 60x (74202) Myeloma, trephine biopsy, kappa 60x (74203) Myeloma, trephine biopsy, lambda 60x (74204)