Letterer-Siwe Histiocytosis
Clinical signs
- a rare disorder
- age: children less than 2 years old
- multiple cutaneous infiltrations with a fast progression
- leukemic form with multiple-organ infiltration: liver, spleen,
lymphatic nodes, bone marrow, lungs
- anemia, thrombocytopenia, secondary infections
- prognosis:
- untreated patients die quickly
- about 50% of patients who undergo aggresive chemotherapy survive the disease
