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Atlas of Bone Marrow pathology
Mojmir Moulis, Josef Feit et al.
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Agranulocytosis
Introduction

Agranulocytosis rarely occures on its own, more often it exists as part of aplastic anemia.

Etiology, pathogenesis

Autoimmune myelopoiesis inhibition, autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus), tumorous diseases (systemic mastocytosis), drugs, toxins.

Histology

Bone marrow is hypocellular, with normal megakaryocytes and normal erythropoiesis. Myelopoiesis is significantly decreased or missing completely. Reactive lymphocytosis and plasmocytosis is usually present.