Etiology, pathogenesis:
Clinical signs:
Clinical signs:
Pictures
SLE, butterfly exanthema:
Systemic lupus erythematodes acute, CLINIC (925)
Acute SLE, butterfly exanthema:
Systemic lupus erythematodes, CLINIC (995)
SLE, butterfly exanthema, discoid:
Discoid lupus erythematodes chronic, CLINIC (993)
Histology:
Vacuolar degeneration of the basal cell layer; perivascular and periadnexal lymphocytic infiltration. The infiltration in the acute erythematodes are usually present neutrohils as well. Fibrosis; occasionally vasculitis.
Immunofluorescence: deposits of all kinds of immune complexes and c3 along the dermo-epidermal junction (also in clinically uninvolved skin); rarely anti-Ro and anti-La antibodies among the cells of the basal layer (subacute LE, SLE, Sjögren's syndrome).
Pictures
SLE, acute:
Systemic lupus erythematodes acute, HE 40x (2288)
Systemic lupus erythematodes acute, HE 40x (2286)
Systemic lupus erythematodes acute, HE 100x (2285)
Another case:
Systemic lupus erythematodes acute, HE 40x (2290)
Another case:
Systemic lupus erythematodes acute, HE 100x (2289)
Another case:
Systemic lupus erythematodes acute, HE 20x (1376)
Another case:
Systemic lupus erythematodes acute, HE 20x (4747) [zoomify]
Acute discoid lupus erythematodes:
Discoid lupus erythematodes fresh, HE 20x (4748)
Another case:
Acute lupus erythematodes, HE 60x (6209)
Acute lupus erythematodes, alcian blue 60x (6208)
Clinical signs:
Affects newborns (more often girls), whose mothers have Ro/SSA antibodies. The symptoms are not visible after the delivery, but appear during the first weeks of life.
Etiology:
IgG antibodies against Ro (SSA) a La (SSB) pass through the placenta and may cause lupus erythematosus in the child. Similar condition may occurr in other autoimmune diseases (Sjögren's syndrome, rheumatoid arthritis).
Histology:
Histological picture correspond to acute lupus erythematosus.
Pictures
Lupus erythematodes of a newborn. In this case the diagnosis
was not evident at first, the child has received blood transfusions
and there was suspition of sepsis with circulating immature
white blood and red blood cells. Immunohistological reaction
to myoglobin was negative, immature white blood cells were
shown by myeloperoxidase reaction. The basal membrane of the
epidermis focally damaged and the amount of mucin in the
corium was slightly increased. The mother had increased
levels of serum antibodies:
Lupus erythematodes, acute, congenital, HE 60x (6277)
Lupus erythematodes, acute, congenital, PAS 60x (6280)
Lupus erythematodes, acute, congenital, alcian blue 60x (6274)
Lupus erythematodes, acute, congenital, Halle 60x (6276)
Lupus erythematodes, acute, congenital, myeloperoxidase 60x (6279)
Lupus erythematodes, acute, congenital, hemoglobin 60x (6278)
Lupus erythematodes, acute, congenital, CD20 60x (6275)
Clinical signs:
Pictures
Annular lesions of the subacute lupus erythematosus:
Lupus erythematodes, subacute, CLINIC (1078)
SCLE, subacute lupus erythematosus of the skin:
Lupus erythematodes, subacute, CLINIC (1079)
Histology:
Vacuolar degeneration of the basal layer; perivascular and periadnexal lymphocytic infiltrate; fibrosis; sometimes vasculitis.
Immunofluorescence: deposits of various kinds of immunocomplexes and C3 along dermo-epidermal junction (the deposits are present in clinically uninvolved skin as well). Direct immunofluorescence sometimes show anti-Ro and anti-La antibodies between the cells of the basal layer (SLE, subacute LE, Sjögren's syndrome).
Pictures
Lupus erythematodes, subacute:
Lupus erythematodes, subacute, HE 20x (213)
Lupus erythematodes, subacute, HE 40x (215)
Lupus erythematodes, subacute, PAS 20x (214)
Lupus erythematodes, subacute, HE 40x (216)
Another case:
Lupus erythematodes subacute, HE 20x (5194)
Lupus erythematodes subacute, HE 10x (1396)
Lupus erythematodes subacute, HE 20x (1397)
Another case:
Lupus erythematodes subacute, HE 40x (4060)
Lupus erythematodes subacute, Halle 40x (4066)
Another case:
Lupus erythematodes subacute, HE 60x (10222)
Lupus erythematodes subacute, alcian blue 60x (10221)
Another case:
Lupus erythematodes subacute, HE 60x (13952)
Clinical signs:
Pictures
Confluent targetoid lesions of the discoid erythematodes, face:
Discoid lupus erythematodes chronic, CLINIC (680)
Fresh lesion, upper lip:
Discoid lupus erythematodes chronic, CLINIC (681)
Chronic cutaneous lupus erythematodes (CDE), butterfly distribution:
Discoid lupus erythematodes chronic, CLINIC (991)
Chronic cutaneous lupus erythematodes (CDE):
Discoid lupus erythematodes chronic, CLINIC (992)
Chronic cutaneous lupus erythematodes (CDE), fresh lesion of the ear:
Discoid lupus erythematodes chronic, CLINIC (994)
Lupus erythematodes, face:
Lupus erythematodes, face, CLINIC (1966)
Chronic discoid lupus erythematodes:
Discoid lupus erythematodes chronic, CLINIC (5737)
Discoid lupus erythematodes chronic, CLINIC (5738)
Discoid lupus erythematodes chronic, CLINIC (5739)
Discoid lupus erythematodes chronic, CLINIC (5740)
Discoid lupus erythematodes chronic, CLINIC (5741)
Discoid lupus erythematodes chronic, CLINIC (5742)
Chronic lupus erythematosus:
Systemic lupus erythematodes, CLINIC (5743)
Systemic lupus erythematodes, CLINIC (5744)
Systemic lupus erythematodes, CLINIC (5745)
Systemic lupus erythematodes, CLINIC (5746)
Systemic lupus erythematodes, CLINIC (5747)
Systemic lupus erythematodes, CLINIC (5748)
Systemic lupus erythematodes, CLINIC (5749)
Systemic lupus erythematodes, CLINIC (5750)
Chronic lupus erythematosus:
Discoid lupus erythematodes chronic, CLINIC (6349)
Histology:
Vacuolar degeneration of the basal layer; perivascular and periadnexal lymphocytic infiltrate; fibrosis; sometimes vasculitis. Follicular plugging, atrophy and/or dysmaturation of the epidermis, thickenning of the basement membrane, lymphocytic periadnexal and perivascular infiltrate.
Immunofluorescence: deposits of various kinds of immunocomplexes and C3 along dermo-epidermal junction (the deposits are present in clinically uninvolved skin as well). Direct immunofluorescence sometimes show anti-Ro and anti-La antibodies between the cells of the basal layer (SLE, subacute LE, Sjögren's syndrome).
Direct immunofluorescence sometimes show anti-Ro and anti-La antibodies between the cells of the basal layer (SLE, subacute LE, Sjögren's syndrome).
Pictures
Lupus erythematodes, chronic:
Chronic lupus erythematosus of the skin, HE 10x (197)
Lupus erythematodes, chronic:
Discoid lupus erythematodes chronic, HE 60x (14040)
Discoid lupus erythematodes chronic, PAS 60x (14041)
Lupus erythematodes, chronic:
Discoid lupus erythematodes chronic, HE 60x (14038)
Discoid lupus erythematodes chronic, PAS 60x (14039)
Another case:
Discoid lupus erythematodes chronic, HE 100x (2523)
Lesion of CDE form the face after long lasting
corticosteroid treatment:
Chronic lupus erythematosus with epidermal atrophy, HE 40x (196)
Another case:
Chronic lupus erythemathosus of the skin, HE 20x (194)
Chronic lupus erythemathosus of the skin, HE 40x (195)
Another case:
Chronic lupus erythematodes of the skin, HE 5x (192)
Chronic lupus erythematodes of the skin, HE 20x (190)
Chronic lupus erythematodes of the skin, HE 40x (191)
Another case:
Discoid lupus erythematodes chronic, HE 40x (6137)
Another case:
Chronic erythematodes of the skin, HE 40x (193)
Another case:
Discoid lupus erythematodes chronic, HE 40x (2706)
Another case:
Discoid lupus erythematodes chronic, HE 20x (5354)
Another case:
Lupus erythematosus, HE 60x (10752)
Another case:
Lupus erythematosus, HE 60x (10753)
Lupus erythematodes:
Discoid lupus erythematodes chronic, HE 60x (12083)
Lupus erythematodes:
Discoid lupus erythematodes chronic, HE 60x (12084)
Lupus erythematodes:
Lupus erythematodes, HE 60x (12018)
Lupus erythematodes:
Lupus erythematodes, HE 60x (12019)
Lupus erythematodes:
Discoid lupus erythematodes chronic, HE 60x (12085)
Lupus erythematodes:
Lupus erythematodes, HE 40x (12619)
Lupus erythematodes:
Lupus erythematodes, HE 40x (12826)
Lupus erythematodes:
Systemic lupus erythematodes, HE 60x (13193)
Systemic lupus erythematodes, HE 40x (12907)
Another case, with dense lymphocytic infiltrates:
Discoid lupus erythematodes chronic, HE 40x (3654)
Another case:
Lupus erythematodes, discoid, HE 60x (10996)
Direct fluorescence in chronic lupus erythematosus
(anti-IgM, FITC):
Chronic lupus erythematodes of the skin, anti-IgM, FITC, Evans 20x (470)
Chronic lupus erythematodes of the skin, anti-IgM, FITC, Evans 40x (471)
Chronic lupus erythematodes of the skin, anti-fibrin, FITC, Evans 10x (535)
Chronic discoid lupus erythematodes, anti-IgM, FITC, Evans 20x (488)
Chronic discoid lupus erythematodes, anti-IgM, FITC, Evans 40x (489)
Lupus erythematodes, anti-IgG, FITC 20x (570)
Lupus erythematodes, anti-IgG, FITC 40x (571)
Discoidní lupus erythematodes chronický, milia (ucho):
Discoid lupus erythematodes chronic, milia (ear), HE 40x (5505)
Alopecia, CDE
Chronic lupus erythematodes, alopecia, HE 10x (490)
Chronic lupus erythematodes, alopecia, HE 10x (491)
Chronic lupus erythematodes, alopecia, HE 40x (492)
Pictures
Lupus erythematosus cutaneus profundus:
Discoid lupus erythematodes chronic, CLINIC (990)
Histology:
Form of chronic lupus erythematosus with dense lymphocytic infiltrates of the deep dermis. Epidermal changes similar to CDE are not present.
Amount of the dermal mucin is increased. Rarely granulomatous infiltrate is present.
Pictures
Lupus erythematosus tumidus:
Lupus erythematodes tumid, HE 20x (4492)
Lupus erythematosus tumidus:
Lupus erythematodes tumid, HE 20x (5195)
Lupus erythematosus profundus:
Lupus erythematodes profundus, HE 40x (2291)
Lupus erythematodes profundus, alcian blue 40x (2364)
Lupus erythematosus profundus:
Lupus erythematodes profundus, HE 20x (5198)
Lupus erythematodes profundus, alcian blue 20x (5197)
Lupus erythematosus, granulomatous reaction resembling necrobiosis lipoidica:
Systemic lupus erythematodes, necrobiosis lipoidica-like granulomatous reaction, HE 20x (4352)
Clinical signs:
Pictures
Dermatomyositis, Gottron's papules:
Dermatomyositis, CLINIC (714)
Dermatomyositis:
Dermatomyositis, CLINIC (4174)
Dermatomyositis, hands, CLINIC (4177)
Paraneoplastic dermatomyositis:
Dermatomyositis, paraneoplastic, forehead, CLINIC (4175)
Dermatomyositis, paraneoplastic, thorax, CLINIC (4176)
Histology:
The picture is that of lupus erythematosus; epidermis is normal or atrophic; dermal edema and increased acid mucopolysaccharides; slight perivascular lymphocytic infiltrate. Old lesion sometimes calcify.
Pictures
Dermatomyositis:
Dermatomyositis, HE 40x (2272)
Dermatomyositis, HE 100x (2270)
Dermatomyositis, HE 100x (2271)
The same case, skeletal muscle biopsy:
Dermatomyositis, muscle, HE 40x (2274)
Dermatomyositis, muscle, acid phosphatase 40x (2275)
Dermatomyositis, muscle, MAC 40x (2273)
Another case, with focal atrophy of the epidermis:
Dermatomyositis, HE 40x (4075)
Another case of dermatomyositis, immunofluorescence:
Dermatomyositis, HE 40x (3480)
Dermatomyositis, HE 40x (3479)
Dermatomyositis, anti-fibrin, FITC 20x (3481)
Dermatomyositis, anti-IgM, FITC 20x (3482)
Dermatomyositis, anti-fibrin, FITC 40x (3483)
Paraneoplastic dermatomyositis, skin, muscle and low
differentiated serous cystadenocarcinoma of the ovary:
Dermatomyositis, paraneoplastic, HE 40x (6220)
Dermatomyositis, paraneoplastic, HE 40x (6221)
Dermatomyositis, paraneoplastic, HE 40x (6227)
Dermatomyositis, paraneoplastic, NADH 20x (6226)
Dermatomyositis, paraneoplastic, ATP 20x (6222)
Dermatomyositis, paraneoplastic, HLA 20x (6223)
Dermatomyositis, paraneoplastic, acid phosphatase 20x (6224)
Dermatomyositis, paraneoplastic, MAC 20x (6225)
Cystadenocarcinoma ovarii, serous, HE 40x (74054)
Another case of dermatomyositis, immunofluorescence:
Dermatomyositis, HE 40x (3513)
Dermatomyositis, HE 40x (3514)
Dermatomyositis, anti-IgG, FITC 20x (3516)
Dermatomyositis necalcifying, early, anti-IgG, FITC 20x (3517)
Dermatomyositis necalcifying, early, anti-IgM, FITC 20x (3518)
Dermatomyositis necalcifying, early, anti-IgG, FITC 20x (3519)
Dermatomyositis, widespread calcifications:
Dermatomyositis, calcifications, HE 10x (204)
Dermatomyositis:
Dermatomyositis, HE 20x (4228) [zoomify]
Dermatomyositis, HE 60x (12004)
Dermatomyositis:
Dermatomyositis, HE 40x (4886) [zoomify]
Dermatomyositis, acute, with edema of papillary dermis:
Dermatomyositis early, HE 20x (4452)
Dermatomyositis:
Dermatomyositis, HE 40x (12809)
Dermatomyositis, slight changes:
Dermatomyositis, HE 60x (10661)
Dermatomyositis, HE 60x (10662)
Clinical signs:
Osteophytes in the distal interphalangeal joints in osteoarthritis are called Heberden nodes; Bouchard nodes affect proximal interphalangeal joints.
Introduction:
Two forms exist: diffuse and localized.
Clinical signs:
Pictures
Sclerodermia diffusa, teleangiectasias, mask-like face:
Scleroderma, CLINIC (821)
Sclerodermia diffusa, sclerodactyly, contractures, vasculitis:
Scleroderma, CLINIC (822)
Scleroderma, CLINIC (1082)
Sclerodermia diffusa, face:
Scleroderma, CLINIC (1083)
Sclerodermia diffusa, face, teleangiectasiae:
Scleroderma, CLINIC (1086)
Skleroderma, hand:
Scleroderma, hand, CLINIC (1980)
Hands, diffuse scleroderma:
Scleroderma, CLINIC (5865)
Scleroderma, CLINIC (5866)
Scleroderma, CLINIC (5867)
Scleroderma, CLINIC (5868)
Scleroderma, CLINIC (5869)
Systemic sclerosis, sclerodermia diffusa:
Scleroderma, CLINIC (3330)
Scleroderma, CLINIC (3331)
Scleroderma, CLINIC (3332)
Scleroderma, CLINIC (3333)
Scleroderma, CLINIC (3334)
Scleroderma, CLINIC (3335)
Clinical signs:
Pictures
Morphea, sacral region:
Morphea, CLINIC (820)
Localized scleroderma (morphea), trunk, with inflammed borders:
Morphea, CLINIC (1075)
Morphea, lilac ring:
Morphea, CLINIC (1076)
Morphea:
Morphea, CLINIC (1077)
Localized scleroderma affecting the tongue and perioral skin:
Scleroderma, CLINIC (1081)
Linear scleroderma:
Scleroderma, CLINIC (1085)
Morphea and lichen sclerosus:
Morphea (and lichen sclerosus), CLINIC (5767)
Lichen sclerosus (and morphea), CLINIC (5769)
Lichen sclerosus (and morphea), CLINIC (5770)
Lichen sclerosus (and morphea), CLINIC (5771)
Histology:
Histological picture of the diffuse and localized forms is the same: perivascular lymphocytic infiltrate, dermal edema, later fibrosis of the dermal connective tissue and epidermal atrophy; dermal connective tissue is sclerotic, sweat glands are entrapped by dermal collagen.
Superficial morphea is limited to the upper parts of the corium.
Pictures
Scleroderma:
Scleroderma, HE 5x (377)
Scleroderma, HE 20x (378)
Another case:
Scleroderma, HE 10x (390)
Scleroderma, HE 20x (391)
Skleroderma:
Scleroderma, HE 20x (4621) [zoomify]
Another case:
Scleroderma, developed, HE 20x (4620) [zoomify]
Another case:
Scleroderma, HE 60x (12527)
Scleroderma, HE 60x (12528)
Another case:
Systemic scleroderma, HE 40x (12853)
Scleroderma, inflammatory stage:
Scleroderma, inflammatory stage, HE 40x (1985)
Skleroderma, advanced:
Scleroderma, HE 60x (12124)
Scleroderma, HE 20x (4982) [zoomify]
Skleroderma:
Scleroderma, HE 40x (12741)
Morphea:
Morphea, HE 10x (323)
Morphea, follicles are destroyed (remnants of pilar smooth muscles):
Morphea, HE 40x (3562)
Another case:
Morphea, HE 40x (2719)
Another case:
Morphea, HE 40x (2424)
Morphea:
Morphea, HE 40x (3616)
Morphea:
Morphea, HE 20x (4548) [zoomify]
Morphea:
Morphea, HE 20x (13957)
Morphea:
Morphea, HE 20x (4549) [zoomify]
Morphea, superficial type:
Superficial morphea, HE 40x (3999)
Superficial morphea, elastic fibres 40x (3998)
Morphea:
Morphea, HE 20x (5210)
Morphea:
Morphea, HE 20x (5364)
Morphea, HE 40x (12829)
Morphea:
Morphea, HE 60x (12478)
Morphea:
Morphea, HE 40x (12830)
Morphea:
Morphea, HE 60x (10690)
Morphea:
Morphea, HE 60x (12704)
Morphea:
Morphea, HE 60x (13206)
Morphea:
Morphea, HE 60x (13742)
Morphea, HE 60x (13743)
Morphea profunda:
Morphea profunda, HE 20x (5209)
Clinical signs:
Pictures
Lichen sclerosus et atrophicus,
candidosis:
Lichen sclerosus at atrophicus, CLINIC (1069)
Craurosis vulvae:
Lichen sclerosus at atrophicus, CLINIC (1070)
Lichen sclerosus et atrophicus:
Lichen sclerosus at atrophicus, CLINIC (1071)
Lichen sclerosus et atrophicus:
Lichen sclerosus at atrophicus, CLINIC (1072)
Lichen sclerosus et atrophicus, penis:
Lichen sclerosus at atrophicus, developed, CLINIC (3081)
Lichen sclerosus at atrophicus, developed, CLINIC (3082)
Lichen sclerosus at atrophicus, developed, CLINIC (3084)
Lichen sclerosus at atrophicus, developed, CLINIC (3085)
Lichen sclerosus at atrophicus, developed, CLINIC (3079)
Lichen sclerosus at atrophicus, developed, CLINIC (3080)
Craurosis vulvae:
Lichen sclerosus at atrophicus, developed, CLINIC (3087)
Lichen sclerosus at atrophicus, developed, CLINIC (3088)
Lichen sclerosus at atrophicus, developed, CLINIC (3077)
Lichen sclerosus at atrophicus, developed, CLINIC (3078)
Craurosis vulvae, CLINIC (5722)
Craurosis vulvae, CLINIC (5723)
Craurosis vulvae, CLINIC (5724)
Craurosis vulvae, CLINIC (5725)
Craurosis vulvae, CLINIC (5726)
Lichen sclerosus et atrophicus:
Lichen sclerosus at atrophicus, developed, CLINIC (3083)
Lichen sclerosus at atrophicus, developed, CLINIC (3086)
Widespread lichen sclerosus et atrophicus:
Lichen sclerosus at atrophicus, CLINIC (6362)
Histology:
Edema of the upper dermis, subepidermal clefts, vacuolar degeneration of basal layer, hyperkeratosis (especially follicular), epidermal atrophy
Pictures
Lichen sclerosus et atrophicus:
Lichen sclerosus et atrophicus, HE 40x (12292)
Lichen sclerosus et atrophicus:
Lichen sclerosus et atrophicus, HE 10x (304)
Lichen sclerosus et atrophicus, HE 40x (305)
Another case, early:
Lichen sclerosus et atrophicus, early, HE 10x (313)
Lichen sclerosus et atrophicus, early, HE 40x (314)
Another case:
Lichen sclerosus et atrophicus, HE 10x (302)
Lichen sclerosus et atrophicus, HE 40x (303)
Another case:
Lichen sclerosus at atrophicus, HE 40x (2559)
Another case:
Lichen sclerosus at atrophicus, HE 40x (12460)
Another case:
Lichen sclerosus at atrophicus, developed, HE 60x (12081)
Another case:
Lichen sclerosus et atrophicus, HE 60x (10755)
Another case:
Lichen sclerosus et atrophicus, HE 60x (10756)
Another case:
Lichen sclerosus at atrophicus, HE 40x (12615)
Another case:
Lichen sclerosus at atrophicus, HE 40x (12616)
Another case:
Lichen sclerosus at atrophicus, developed, HE 60x (13892)
Another case:
Lichen sclerosus at atrophicus, HE 40x (12617)
Lichen sclerosus at atrophicus, HE 40x (12618)
Lichen sclerosus and melanocytic nevus:
Lichen sclerosus with melanocytic nevus, HE 60x (14056)
Bullous lichen sclerosus:
Lichen sclerosus at atrophicus bullous, HE 40x (4185)
Bulózní lichen sclerosus:
Lichen sclerosus at atrophicus bullous, HE 40x (4727) [zoomify]
Kraurosis vulvae (lichen sclerosus et atrophicus of the vulva):
Kraurosis vulvae, HE 5x (291)
Kraurosis vulvae, HE 40x (290)
Another case of craurosis vulvae:
Lichen sclerosus at atrophicus (kraurosis vulvae), HE 40x (4091)
Lichen sclerosus et atrophicus, fluorescence:
Lichen sclerosus et atrophicus, anti-IgM, FITC 20x (1908)
Clinical signs:
Histology:
Slight acanthosis, thick collagen bundles, slightly increased amount of mucin, increased number of fibroblasts. Slight perivascular and periadnexal lymphocytic infiltrate.
Pictures
Pachydermoperiostosis:
Pachydermoperiostosis, HE 20x (4917) [zoomify]
Clinical signs:
Histology:
Thickened subcutaneous septa and deep fascia, with variable inflammatory infiltrate with plasmocytes and often (not always) eosinophils.
Pictures
Eosinophilic fasciitis:
Eosinophilic fasciitis, HE 20x (4477) [zoomify]
Eosinophilic fasciitis:
Eosinophilic fasciitis, HE 2.5x (1286)
Eosinophilic fasciitis, HE 20x (1285)
Eosinophilic fasciitis, HE 20x (1284)
Another case:
Eosinophilic fasciitis, HE 20x (5102) [zoomify]
Eosinophilic fasciitis, HE 20x (5103) [zoomify]
Clinical signs:
Pictures
Dupuytren's contracture:
Fibromatosis palmaris Dupuytren, CLINIC (2849)
Fibromatosis palmaris Dupuytren, CLINIC (2850)
Fibromatosis palmaris Dupuytren, CLINIC (2851)
Fibromatosis palmaris Dupuytren, CLINIC (2852)
Fibromatosis palmaris Dupuytren, CLINIC (2853)
Histology:
Nodules and fascicles of fibroblasts, slight mitotic activity.
Pictures
Dupuytren's contracture:
Dupuytren contracture, HE 60x (13709)
Plantar fibromatosis of Lederhose:
Plantar fibromatosis of Lederhose, HE 40x (6140)
Histology:
Intravascular fasciitis is benign fibroblastic proliferation closely associated with blood vessels, arising in deep soft tissues and fascia. Fasciitis consists of myxoid proliferation of spindle cells with little atypia.
Clinical signs:
Histology:
Elongated spindle cells in bundles, infiltrative growth. Vimentin and smooth muscle actin positive.
Pictures
Desmoid:
Desmoid, HE 20x (4453) [zoomify]
Histology:
Fibrosis, degenerative changes in the grafted skin.
Pictures
Skin graft, face (after incomplete excision of a squamous cell carcinoma:
Transplanted skin, margin of the skin graft, HE 20x (3392)
Clinical signs:
Pictures
Reactive perforating collagenosis (histology see bellow, 6330, 6329):
Collagenosis perforans, CLINIC (13322)
Collagenosis perforans, CLINIC (13321)
Histology:
Focus of thinned epidermis with transepidermal elimination of collagen fibres and dermal inflammation. Sometimes the defect is complete and collagen fibres can be seen in necrotic tissue covered by parakeratotic plug.
Pictures
Perforating collagenosis:
Collagenosis perforans, HE 20x (4744) [zoomify]
Another case, HIV positive patient:
Collagenosis perforans, HE 20x (4745)
Perforating collagenosis:
Collagenosis perforans, HE 60x (6330)
Collagenosis perforans, elastic fibres 60x (6329)