Introduction:
Tissue nevi and malformations, affecting skin and adnexa. Other malformation (eg. malformaltions of the blood vessels) are mentioned elsewhere.
Clinical signs:
Histology:
Epidermal nevus papillary lesion with hyperkeratosis, almost without parakeratosis, inflammatory changes are minimal or none.
Inflammatory linear verrucous epidermal nevus (ILVEN) is characterized by psoriatiform acanthosis, focal columnar parakeratosis and inflammation (lymphocytes within the epidermis).
Sebaceous nevus is more complex: papillomatosis, hyperplasia of sebaceous glands (develops at puberty, not prominent in children), malformed sweat glands are often present.
Clinical signs:
Pictures
Nevus sebaceus, upper lip:
Nevus sebaceus, lips, CLINIC (848)
Histology:
Hyperkeratosis, papillomatosis, dilated follicles, accumulated sebaceous glands (during and after puberty). In addition malformed sweat glands are often present and in about 20% of cases syringocystadenoma papilliferum is found as well. Trichoepithelial induction resembling basalioma is common.
Pictures
Nevus sebaceus Jadassohn:
Nevus sebaceus of Jadassohn, HE 40x (5511)
Another case:
Nevus sebaceus of Jadassohn, HE 40x (4905)
Nevus sebaceus:
Nevus sebaceus, HE 2.5x (1506)
Nevus sebaceus, HE 10x (1505)
Another case:
Nevus sebaceus, HE 20x (2578)
Another case:
Nevus sebaceus, HE 20x (2504)
Another case:
Nevus sebaceus, HE 40x (10941)
Another case:
Nevus sebaceus, HE 2x (1915)
Nevus sebaceus, HE 5x (1916)
Nevus sebaceus, HE 10x (1918)
Nevus sebaceus, HE 10x (1917)
Nevus sebaceus, HE 40x (1920)
Nevus sebaceus, HE 40x (1919)
Clinical signs:
Pictures
Epidermal nevus:
Nevus epidermal, CLINIC (5773)
Histology:
Prominent hyperkeratosis, papillomatosis, variable acanthosis, sometimes epidermolytic hyperkeratosis (granular degeneration of the epidermis) or dyskeratosis, acantholysis and other changes.
Pictures
Epidermal verrucous nevus:
Linear epidermal nevus, HE 20x (4479)
Epidermal nevus:
Epidermal nevus, HE 10x (1272)
Epidermal nevus, HE 20x (1273)
Nevus epidermal, HE 40x (1890)
Another case:
Linear epidermal nevus, HE 2.5x (1501)
Linear epidermal nevus, HE 10x (1500)
Another case:
Nevus epidermal, HE 40x (2388)
Another case (newborn with tuberous sclerosis, lesion of the arm):
Nevus epidermal, HE 40x (2350)
Another case, 10 years old boy, forhead:
Nevus epidermal (10 years old boy, forhead), HE 20x (2668)
Another case:
Nevus epidermal, HE 40x (2669)
Linear epidermal nevus with epidermolytic hyperkeratosis
(linearly arranged lesion, child):
Linear epidermal nevus, epidermolytic variant, HE 40x (3688)
Another case of epidermal nevus with epidermolytic hyperkeratosis, boy,
multiple congenital large linear lesions of the trunk:
Epidermal epidermolytic nevus, HE 40x (6073)
Epidermal nevus of the scalp:
Nevus epidermal, HE 20x (4237) [zoomify]
Histology:
Prominent hyperkeratosis, focal epidermolysis, acanthosis, papillomatosis, bacterial and mycotic colonization of almost whole body surface.
Pictures
Case of ichthyosis hystrix:
2 years old child with very large areas of hyperkeratosis,
papillomatosis, desquamation, madidation and chronic
bacterial and mycotic colonization of the skin.
The lesions were partially present at birth.
Chronic sepsis. Autoptic specimen.
Ichthyosis hystrix, HE 20x (566)
Ichthyosis hystrix, Grocott 20x (567)
Ichthyosis hystrix, Grocott 40x (568)
Ichthyosis hystrix:
Ichthyosis hystrix, HE 20x (4713) [zoomify]
Ichthyosis hystrix:
Ichthyosis hystrix, HE 20x (4714) [zoomify]
Clinical signs:
Histology:
Hyperkeratosis, parakeratosis (parakeratotic areas alternate with orthokeratotic); psoriatiform acanthosis; papillomatosis; often slight spongiosis and lymphocytic exocytosis.
Pictures
ILVEN:
Inflammatory linear epidermal nevus (ILVEN), HE 40x (2524)
Another case:
Inflammatory linear epidermal nevus (ILVEN), HE 5x (1351)
Another case:
Inflammatory linear epidermal nevus (ILVEN), HE 20x (4716) [zoomify]
Clinical signs:
Pictures
Nevus comedonicus linearis of Blaschko:
Nevus comedonicus Blaschko linearis, CLINIC (3143)
Nevus comedonicus Blaschko linearis, CLINIC (3144)
Nevus comedonicus Blaschko linearis, CLINIC (3145)
Nevus comedonicus Blaschko linearis, CLINIC (3146)
Nevus comedonicus Blaschko linearis, CLINIC (3147)
Nevus comedonicus Blaschko linearis, CLINIC (3148)
Nevus comedonicus Blaschko linearis, CLINIC (3149)
Nevus comedonicus Blaschko linearis, CLINIC (3150)
Nevus comedonicus Blaschko linearis, CLINIC (3151)
Histology:
Comedones filled with keratin; sometimes combined with other organoid nevi; no dyskeratosis. Sometimes combined with inflammation.
Clinical signs:
Clinical signs:
Histology:
Acanthotic hyperplasia of oral mucosa, focal intracellular edema of keratinocytes, parakeratosis.
Pictures
White sponge nevus:
White sponge nevus, HE 2.5x (1843)
White sponge nevus, HE 10x (1842)
White sponge nevus, HE 40x (1762)
White sponge nevus:
White sponge nevus, HE 20x (4643)
White sponge nevus:
White sponge nevus, HE 20x (4644)
White sponge nevus:
White sponge nevus, HE 20x (5071)
Clinical signs:
Histology:
Groups of mature, normal fat cells within the dermis, varying amount.
Pictures
Nevus lipomatosus:
Nevus lipomatosus, HE 1.25x (1504)
Nevus lipomatosus, HE 10x (1503)
Nevus lipomatosus:
Nevus lipomatosus, HE 40x (10240)
Another case:
Nevus lipomatosus, HE 20x (2117)
Superficial nevus lipomatosus:
Nevus lipomatosus, superficial, HE 20x (2116)
Nevus lipomatosus with missing sweat glands:
Nevus lipomatosus, HE 20x (14016)
Histology:
Focus of thickenned dermis with increased collagen and variable presence of elastic fibres. No or very slight inflammation.
Pictures
Nevus collagenicus:
Collagenous nevus, HE 20x (4106)
Collagenous nevus, HE 40x (4090)
Clinical signs:
Histology:
Mixture of bundles of spindle cells, fat and pale myxoid areas forming organoid structures.
Pictures
Fibrous hamartoma of infancy:
Fibrous hamartoma of children, HE 20x (4182)
Clinical signs:
Histology:
Epidermal defect, no hair follicles. The surface may be covered by very thin epithelial layer. Later scarring.
Pictures
Aplasia cutis congenita, 31 — week stillborn infant; trisomy 13 (Patau),
macroscopic and microscopic picture:
Aplasia cutis congenita, Macro, autopsy (6037)
Aplasia cutis congenita, HE 40x (6032)