Introduction:
Some drug reactions can have lichenoid appearance
Pictures
Lichenoid drug eruption:
Lichenoid drug reaction, HE 10x (309)
Lichenoid drug reaction, HE 20x (310)
Lichenoid drug reaction, HE 20x (311)
Lichenoid drug reaction, HE 40x (312)
Drug reaction (Tensamine), resembling lichen ruber:
Lichen vesiculosus, drug related (Tensamine), HE 5x (308)
Lichen vesiculosus, drug related (Tensamine), HE 10x (306)
Lichen vesiculosus, drug related (Tensamine), HE 20x (307)
Another case:
Lichenoid drug reaction, HE 10x (474)
Lichenoid drug reaction, HE 40x (475)
Lichenoid drug reaction, anti-fibrin, FITC, Evans 20x (473)
Lichenoid drug reaction, anti-fibrin, FITC, Evans 40x (472)
Lichenoid drug reaction, dyskeratosis:
Drug reaction, lichenoid, dyskeratotic, HE 60x (12175)
Lichenoid drug eruption, gold:
Gold dermatitis, HE 20x (4271)
Lichenoid drug reaction (gold), HE 10x (1408)
Lichenoid drug reaction (gold), HE 40x (1409)
Another case of lichenoid drug eruption, gold:
Gold dermatitis, HE 20x (4270) [zoomify]
Lichenoid drug eruption, drug caused lichen ruber:
Drug related lichen ruber, HE 60x (14007)
Introduction:
Drug reaction with histological signs of eczema dermatitis.
Pictures
Eczematoid drug reaction:
Drug reaction, eczematoid, HE 60x (10745)
Drug reaction, eczematoid, HE 60x (10746)
Introduction:
Drug reaction, histologicaly resembling erythema multiforme (necrotic keratinocytes, variable lymphocytic infiltrate, edema of the papillary corium and sometimes even subepidermal vesicle.
Pictures
Drug reaction, multiform type, dyskeratoses:
Drug reaction, HE 40x (12863)
Drug reaction, multiform type, dyskeratoses, ev. inicial erythema multiforme:
Drug reaction, HE 40x (12864)
Clinical signs:
Pictures
Exanthema fixum, breast:
Fixed drug reaction, CLINIC (736)
Erythema fixum, penis:
Fixed drug reaction, CLINIC (2897)
Erythema fixum bullosum, penis:
Fixed drug reaction, CLINIC (2897)
Fixed drug reaction bullous, CLINIC (2903)
Fixed drug reaction bullous, CLINIC (2904)
Fixed drug reaction bullous, CLINIC (2905)
Erythema fixum bullosum, leg:
Fixed drug reaction bullous, CLINIC (2902)
Erythema fixum, leg and hand:
Fixed drug reaction, CLINIC (2906)
Fixed drug reaction, CLINIC (2898)
Fixed drug reaction, CLINIC (2899)
Erythema fixum, scrotum:
Fixed drug reaction, CLINIC (2908)
Fixed drug reaction, CLINIC (2900)
Erythema fixum, penis:
Fixed drug reaction bullous, CLINIC (2901)
Histology:
Vacuolar alteration of the basal layer, pigment incontinence, dyskeratoses, slight (variable) parakeratosis, fibrosis of the papillary dermis.
Pictures
Fixex drug reaction:
Fixed drug reaction, HE 60x (10168)
Clinical signs:
Pictures
Generalized toxoallergic reaction to iodine:
Toxoalergic exanthema, CLINIC (733)
Toxoallergic exanthema after Diacordin:
Toxoalergic exanthema, CLINIC (734)
Toxoallergic exanthema:
Toxoalergic exanthema, CLINIC (735)
Toxoallergic exanthema (Glyvenol):
Toxoalergic exanthema, CLINIC (1052)
Exanthema toxoalergicum :
Toxoalergic exanthema, CLINIC (1053)
Exanthema toxoalergicum:
Toxoalergic exanthema, CLINIC (1054)
Allergic exanthema caused by atenolol:
Allergic exanthema caused by atenolol, CLINIC (5963)
Allergic exanthema caused by erythromycin:
Allergic exanthema caused by erythromycin, CLINIC (5964)
Allergic exanthema caused by paralen or penicillin, compared with normal skin:
Allergic exanthema caused by paralen or penicillin, CLINIC (5965)
Allergic exanthema caused by paralen or penicillin, comp. with normal skin, CLINIC (5966)
Toxoallergic exanthema, old warfarinized woman:
Toxoallergic exanthema, warfarinized woman, CLINIC (5978)
Toxoallergic exanthema, warfarinized woman, CLINIC (5979)
Introduction:
Drug reaction in acute form may form vesicles or bullae (often subepidermal).
Pictures
Vesicular drug reaction, subepidermal:
Bullous drug eruption, HE 20x (4470)
Bullous drug eruption, HE 20x (4471)
Drug reaction with intraepidermal bulla:
Bullous drug eruption, HE 20x (4471)
Pemphigoid-like reaction to vaccination, child:
Pemphigoid-like vaccination reaction, HE 60x (12835)
Pemphigoid like reaction to vaccination, child, HE 60x (13228)
Another pemphigoid-like reaction to vaccination, child:
Bullous pemphidoid vaccination reaction, HE 60x (10009)
Bullous pemphidoid vaccination reaction, HE 60x (10010)
Residual postvaccination reaction:
Residual vaccination, HE 60x (13959)
Histology:
Pustular drug reaction closely resembles active psoriasis.
Pictures
Pustular drug reaction:
Drug reaction, pustular, HE 10x (1822)
Drug reaction, pustular, HE 40x (1823)
Introduction:
EGFR (epidermal growth factor receptor) is a cell surface receptor, whose mutations (overexpression) are associated with cancerogenesis. EGFR inhibitors are used in therapy of various tumors, namely carcinomas of the lung and colon. Testing for EGFR overexpression is important to estimate the outcome of EGFR inhibitors therapy.
Etiology:
Purulent folliculitis is an obligatory side effect of the therapy (present in more than two thirds of patients) and may be a marker for tumor response.
Pictures
Papulopustular exanthema, EGFR inhibitors:
Drug reaction, EGFR, papulopustulous, CLINIC (6344)
Drug reaction, EGFR, papulopustulous, CLINIC (6345)
Drug reaction, EGFR, pustulous, CLINIC (6346)
Drug reaction, EGFR, papulopustulous, CLINIC (6352)
Paronychia, EGFR inhibitors:
Drug reaction, EGFR, paronychia, CLINIC (6353)
Trichomegaly, EGFR inhibitors:
Drug reaction, EGFR, trichomegaly, CLINIC (6354)
Xerosis cutis, EGFR inhibitors:
Drug reaction, EGFR, xerosis cutis, CLINIC (6355)
Impetigo, EGFR inhibitors dermatitis:
Drug reaction, EGFR, impetiginized, CLINIC (6359)
Histology:
Perifollicular T lymphocytic infiltrate, neutrophilic infiltrate, sterile, especially at infundibular area. No comedones are formed, sebaceous glands are spared.
Pictures
EGFR inhibitors therapy, folliculitis:
Purulent folliculitis, anti-EGFR therapy, HE 60x (6400)
Another case:
Folliculitis purulent, EGFR, HE 60x (6317)
Another case, with granulomatous reaction:
Folliculitis purulent, EGFR, HE 60x (6319)
Folliculitis purulent, EGFR, HE 60x (6318)
Another case:
Folliculitis purulent, EGFR, HE 60x (6320)
Another case:
Folliculitis purulent, EGFR, HE 60x (6321)
Another case:
Folliculitis purulent, EGFR, HE 60x (6322)
Another case, slight epidermal changes in xerosis cutis, superficial epidermal defect:
Drug reaction, EGFR, HE 60x (6332)
Drug reaction, EGFR, HE 60x (6331)
Drug reaction, EGFR, HE 60x (6333)
Drug reaction, EGFR, HE 60x (6334)
Another case of folliculitis:
Drug reaction, EGFR inhibitors therapy, HE 60x (10028)
Drug reaction, EGFR inhibitors therapy, HE 60x (10029)
EGFR inhibitor therapy, folliculitis, Tarceva:
Folliculitis purulent, Tarceva, HE 60x (10068)
EGFR inhibitor therapy, folliculitis, Tarceva:
Folliculitis, Tarceva therapy, HE 60x (10170)
Folliculitis, Tarceva therapy, PAS 60x (10171)
Folliculitis, Tarceva therapy, Gram 60x (10169)
Introduction:
Inhibitors of tumor nenecrotizing factor alpha have antiinflammatory influence (Infliximab, Adalimumab). There are many side effects of the therapy: erythema, leukocytoclastic vasculitis, local reactions, eczematoid urticarial, granulomatous and psoriatiform reactions, generalized infections — mycotic, viral and mycobacterial.
Pictures
Drug reaction, Humira:
Drug reaction, Humira therapy, HE 60x (6300)
Drug reaction, Humira therapy, HE 60x (6301)
Monoclonal antibody against TNF-α (Infliximab):
Infliximab therapy, HE 60x (10189)
Infliximab therapy, HE 60x (10190)
Infliximab therapy, HE 60x (10191)
Infliximab therapy, HE 60x (10192)
Palmoplantar pustulosis, Humira therapy (rheumatoid arthritis):
Pustulosis palmaris, Humira, HE 60x (13783)
Histology:
Bcr-Abl tyrosinkinase inhibitors are used in chronic myeloic leukemia therapy.
Pictures
Nilotinib, Bcr-Abl tyrosinkinase inhibitor, chronic myeloic leukemia therapy:
Reaction to nilotinib therapy, HE 40x (10244)
Tasigna (nilotinib), Bcr-Abl tyrosinkinase inhibitor, chronic myeloic leukemia therapy:
Folliculitis, Tasigna therapy, HE 60x (10800)
Nilotinib, Bcr-Abl tyrosinkinase inhibitor, myeloic leukemia therapy:
Nilotinib therapy, HE 40x (10590)
Nilotinib therapy, HE 40x (10591)
Nilotinib therapy, HE 40x (10592)
Nilotinib therapy, HE 40x (10593)
Nilotinib therapy, Giemsa 40x (10594)
Introduction:
Some drug reactions with fulminant course are accompanied with widespread epidermal necroses (see toxic necrolysis of Lyell or erythema multiforme).
Pictures
Widespread drug reaction:
Widespread drug reaction, CLINIC (1964)
Introduction:
Drug reactions have often unspecific histological appearance. Clinical information is necessary to make the diagnosis.
Histology:
Dermal infiltrate with variable admixture of eosinophils.
Pictures
Drug reaction:
Drug reaction, HE 60x (10663)
Drug reaction:
Drug reaction, HE 60x (10664)
Drug reaction, HE 60x (10665)
Introduction:
After administration of anticoagulative drugs with coumarine content skin necroses may develop. Coumarin therapy (warfarin) can cause dermal bleeding.
Pictures
Coumarin necrosis:
Coumarin necrosis, HE 20x (4440) [zoomify]
Hemorrhagic diathesis after warfarin overdosis:
Warfarin overdosing, bleeding, CLINIC (5579)
Warfarin overdosing, bleeding, CLINIC (5580)
Pictures
Striae after prolonged therapy by corticosteroids:
Striae after long lasting application of corticosteroids, CLINIC (3352)
Histology:
Epidermis is thinned, dermal elastic fibres are fragmented.
Pictures
Striae distensae, GVHD treated with corticosteroids:
Striae distensae, HE 20x (4360) [zoomify]