Clinical signs:
Pictures
Actinic keratosis, head; the size and hemorrhagic crust are
suspicious of change into squamous carcinoma:
Actinic keratosis, CLINIC (653)
Multiple actinic keratoses:
Actinic keratosis, CLINIC (962)
Actinic keratoses:
Actinic keratosis, CLINIC (963)
Actinic keratosis:
Solar keratosis, CLINIC (3051)Solar keratosis, CLINIC (3052)
Further examples of actinic keratosis:
Histology:
Intraepidermal carcinoma, characterised by dysplastic keratinocytes (especially in lower third of the epidermis). In some cases the acantholysis is present (lower part of the epidermis). Parakeratosis, sometimes hyperkeratosis.
Several forms: atrophic, acantholytic, hyperkeratotic.
Common features are dysplastic epithelium with mitotic activity and loss of dermal polarity. The dysplastic epithelium usually spreads down into the epithelium of the hair follicles.
Later infiltrative growth and transition into low grade squamous carcinoma.
Pictures
Solar keratosis (actinic keratosis), atrophic:
Solar (actinic) keratosis, atrophic, HE 20x (1962)
Another case of solar keratosis:
Solar keratosis, HE 40x (2568)
Another case of solar keratosis:
Solar keratosis, HE 60x (6408)
Another case of solar keratosis:
Actinic keratosis, HE 60x (10749)Actinic keratosis, HE 60x (10750)
Solar keratosis:
Solar keratosis atrophic, HE 40x (12952)
Solar keratosis vs m. Bowen vs large cell acanthoma:
Actinic keratosis or m. Bowen or large cell acanthoma, HE 60x (12315)
Solar keratosis:
Solar keratosis, HE 40x (12787)Solar keratosis, HE 40x (12788)
Solar keratosis:
Solar keratosis, HE 60x (13033)
Solar keratosis:
Solar keratosis, HE 60x (12074)
Solar keratosis:
Solar keratosis, HE 60x (14019)
Lichenoid solar keratosis:
Actinic keratosis, lichen planus-like, HE 60x (12012)
Solar keratosis, hyperkeratotic:
Solar keratosis hyperkeratotic, HE 20x (4389) [zoomify]
Solar keratosis, bowenoid:
Solar keratosis bowenoid, HE 60x (13684)
Cornu cutaneum based on solar keratosis:
Cornu cutaneum, HE 20x (5275)
Solar keratosis, lewandovsky-like:
Solar keratosis, HE 20x (4984) [zoomify]
Lichenoid solar keratosis:
Solar keratosis lichen planus like, HE 40x (12073)
Clinical signs:
Histology:
Cellular atypia, chronic inflammation with many plasma cells, ortho- and parakeratosis.
Pictures
Cheilitis solaris:
Cheilitis, actinic, HE 40x (4126)
Clinical signs:
Pictures
Morbus Bowen, detail:
Bowen's disease, CLINIC (977)
Morbus Bowen, calf:
Bowen's disease, CLINIC (978)
Morbus Bowen, temple:
Bowen's disease, CLINIC (979)
Multiple foci of Bowen's disease, changing into squamous cell
carcinoma:
Spinalioma, CLINIC (983)
Further examples of Bowen's carcinoma:
Histology:
Dysplastic epithelium of high mitotic activity, usually within the full thickness of the epidermis, but the changes are sometimes less pronounced within the basal layer. Parakeratosis, hyperkeratosis, spread into the epithelium of hair follicles and sweat glands. After some time infiltrative growth.
Epidermis is often acanthotic and thickened. Malignant keratinocytes are sometimes pale (glycogen) and may form variable, usually irregular nests within the epidermis.
Pictures
Bowen's intraepidermal carcinoma:
Bowen's carcinoma, HE 20x (1944)
Another case:
Bowen's carcinoma, HE 40x (1946)
Another case:
Bowen's carcinoma, HE 20x (2614)Bowen's carcinoma, HE 100x (2613)
Another case:
Bowen's carcinoma, HE 40x (2831)
Another case:
Bowen's carcinoma, ear, HE 20x (5997)
Another case:
Bowen's carcinoma, HE 40x (2615)
Another case:
Bowen's carcinoma, HE 60x (12025)
Another case:
Bowen's carcinoma, HE 40x (12801)
Another case:
Bowen's carcinoma, HE 40x (12802)
Another case:
M. Bowen, HE 60x (10759)M. Bowen, HE 60x (10760)
Another case:
Bowen's carcinoma, HE 60x (10789)Bowen's carcinoma, HE 60x (10790)
Another case:
Bowen's carcinoma, HE 60x (14037)
Hypertrophic m. Bowen:
M. Bowen, hypertrophic, HE 40x (12656)
Bowen's intraepidermal carcinoma, clear cells:
Bowen's intraepidermal carcioma, clear cell variant, HE 2.5x (1213)Bowen's intraepidermal carcioma, clear cell variant, HE 20x (1212)
Another case:
Bowen's carcinoma, HE 100x (3569)Bowen's carcinoma, HE 40x (3570)
Clonal Bowen's disease:
Bowen's carcinoma, nested, HE 40x (5406)Bowen's carcinoma, nested, CK7 40x (5405)Bowen's carcinoma, nested, S100 40x (5407)Bowen's carcinoma, nested, Ki67 40x (5434)
Cornu cutaneum caused by Bowen's carcinoma:
Bowen's carcinoma in the form of the cutaneous horn, HE 20x (4732) [zoomify]
Introduction:
Morbus Bowen was described in 1912 by John T. Bowen and is regarded as a squamous cell carcinoma in situ. It is spreading superficially, progression to the invasive squamous cell carcinoma and metastases are rare. There are several variants of the disease:
Pigmented variant on extra-genital skin is uncommon; clinically it can be misdiagnosed as melanoma. A subungual variant with melanonychia was described, too.
History:
A 60-year-old man presented with many actinic keratoses of the sun-exposed areas. He was a phototype II, he suffered sunburn repeatedly in his active years (he had worked in Africa). At the clinical examination a red flat lesion with some brown pigment was found on his right arm. The patient had the lesion for many years; it was growing slowly, and was asymptomatic. Dermatoscopically there was no pigment net. The lesion was excised completely.
Clinical signs:
Red flat lesion 35×20 mm with irregular, sharply demarcated borders, some scaling, and a rim of brown pigment on the right arm. There was no lymphadenopathy. The patient had multiple actinic keratoses on the face, dorsal aspects of the hands, and upper back.
Pictures
Pigmented Bowen disease, simulating melanoma:
Bowen's intraepidermal carcinoma, pigmented, CLINIC (4173)Bowen's disease, pigmented, CLINIC (6154)
Histology:
Irregular nests of atypical cells with pigment and mitotic activity in the epidermis. The cells are AE1/AE3 positive, Melan A is positive only in solitary cells. In some parts the tumor bears resemblance to superficial basal cell carcinoma, however the nests are intraepidermal, formed by bowenoid cells.
Diagnosis: Clonal pigmented variant of Bowen intraepidermal carcinoma.
Pictures
Clonal Bowen carcinoma, forming intraepidermal nests of slightly
pigmented keratinocytes, simulating melanoma:
Bowen's carcinoma, clonal, HE 40x (4116)Bowen's carcinoma, clonal, AE13 40x (4115)Bowen's carcinoma, clonal, Melan A 40x (4117)
Histology:
Variant of Bowen's disease with pale keratinocytes (glycogen), scattered within the epidermis (single or within small nests).
Pictures
Bowen's disease, pagetoid:
Bowen's intraepidermal carcioma, pagetoid, HE 10x (1210)Bowen's intraepidermal carcioma, pagetoid, HE 40x (1211)
Bowen's intraepidermal carcinoma with clonal nests of malignant keratinocytes within the epidermis, PAS negative:
Bowen's carcinoma, clonally arranged, with transition into a squamous cell carcinoma, HE 40x (4004)Bowen's carcinoma, clonally arranged, with transition into a squamous cell carcinoma, PAS 40x (4005)
Pagetoid Bowen's intraepidermal carcinoma:
Bowen's carcinoma, pagetoid, HE 20x (4568)Bowen's carcinoma, pagetoid, HE 20x (4911)Bowen's carcinoma, pagetoid, HE 20x (4912)Bowen's carcinoma, pagetoid, CEA 20x (4907)Bowen's carcinoma, pagetoid, MAGE4 20x (4908)Bowen's carcinoma, pagetoid, MAGE4 20x (4909)Bowen's carcinoma, pagetoid, S100 20x (4910)
Another case of pagetoid Bowen's intraepidermal carcinoma:
Bowen's carcinoma, pagetoid, HE 40x (4730) [zoomify]
Another case:
Bowen's disease, pagetoid (clonal), HE 40x (3627)
Histology:
Intraepidermal carcinoma, corresponding to the Bowen's disease, but localized on the penis.
Pictures
Queyrat's disease:
Queyrat's carcinoma of the penis, HE 20x (1654)
Another case:
Queyrat's intraepithelial carcinoma of the penis, HE 20x (3468)
Another case:
Queyrat's carcinoma of the penis, HE 40x (4068)
Histology:
Vulval intraepithelial neoplasia in high grade (VIN III.) coresponds to the Bowen's disease or Queyrat's disease, but is localized on the vulva.
Multinuclear atypia of the vulva is different entity, where multinuclear cells are present within the lower layers of the epithelium; other keratinocytes are without atypia.
Pictures
Vulval intraepithelial neoplasia, VIN III.:
Vulval intraepithelial neoplasia gr. III (VIN 3), HE 60x (10070)Vulval intraepithelial neoplasia gr. III (VIN 3), HE 60x (10071)
Introduction:
M. Queyrat variant. Usually in HIV positive patients.
Histology:
Basophilic cells replace the whole thickness of the epithelium. Dysplastic changes, mitotic activity.
Pictures
Basaloid in situ carcinoma of the penis:
Carcinoma in situ/high grade dysplasia, penis, basaloid type, HE 60x (10011)
Clinical signs:
The lesion is characterised by prominent hyperkeratosis. The origin varies (solar keratosis, vulgar verruca or some other hyperkeratotic process).
Pictures
Cornu cutaneum, scrotum:
Cornu cutaneum, CLINIC (996)
Cornu cutaneum, face:
Cornu cutaneum, CLINIC (997)
Cornu cutaneum, ear:
Cornu cutaneum, CLINIC (2854)Cornu cutaneum, CLINIC (2855)
Cornu cutaneum, neck:
Cornu cutaneum, Macro (3732)Cornu cutaneum, Macro (3733)Cornu cutaneum, Macro (3735)Cornu cutaneum, Macro (3980)
Cornu cutaneum, forhead:
Cornu cutaneum, forhead, CLINIC (5562)Cornu cutaneum, forhead, CLINIC (5563)Cornu cutaneum, forhead, CLINIC (5564)Cornu cutaneum, forhead, CLINIC (5565)
Cornu cutaneum, penis:
Cornu cutaneum of the penis, CLINIC (5566)
Histology:
Histology is variable, but massive hyperkeratosis is present, usually wiht parakeratosis.
Epithelium is often dysplastic.
Pictures
Cornu cutaneum, macroscopic and microscopic picture:
Cornu cutaneum, macro, CLINIC (3477)Cornu cutaneum, HE 10x (3473)Cornu cutaneum, HE 20x (3474)Cornu cutaneum, HE 40x (3475)Cornu cutaneum, HE 40x (3476)
Cornu cutaneum:
Cornu cutaneum, HE 60x (12031)
Cornu cutaneum:
Cornu cutaneum, HE 40x (12808)
Cornu cutaneum, actinic keratosis:
Cornu cutaneum, HE 20x (4224) [zoomify]
Cornu cutaneum, squamous cell carcinoma, ear:
Cornu cutaneum, HE 60x (12353)
Introduction:
Rare form of cornu cutaneum, characterized by trichilemmal keratinization within the tumor.
Pictures
Trichilemmal cornu cutaneum:
Trichilemmal cornu cutaneum, HE 60x (6183)
Trichilemmal cornu cutaneum:
Trichilemmal cornu cutaneum, HE 20x (5040) [zoomify]
Clinical signs:
Pictures
Multiple basaliomas with pigment in hereditary syndrome of Gorlin:
Basalioma, CLINIC (663)
Basalioma, typical location at the base of the nose:
Basalioma, CLINIC (664)
Flat, inconspicuous carcinoma of the nose:
Basalioma, CLINIC (665)
Ulcerating basalioma with typical pearly border and scarring:
Basalioma, CLINIC (666)
Ulcerating basalioma, scalp:
Basalioma, CLINIC (667)
Ulcerating basalioma with hemorrhagic crust, temple:
Basalioma, CLINIC (668)
Ulcerating basalioma (ulcus rodens):
Basalioma, ulcus rodens, CLINIC (3400)
Basalioma:
Basalioma, ulcus rodens, CLINIC (3401)
Ulcerating basalioma, lower extremity:
Basalioma, CLINIC (966)
Ulcerating basalioma with pearly border:
Basalioma, CLINIC (967)
Ulcus rodens:
Basalioma, ulcus rodens, CLINIC (5545)
Ulcus rodens:
Basalioma, ulcus rodens, CLINIC (5546)
Smooth scar after cryotherapy of basalioma:
Basalioma, CLINIC (968)
Scarring and ulcerationg basalioma, nose:
Basalioma, CLINIC (969)
Nodular basalioma:
Basalioma, CLINIC (970)
Basalioma, nose (+ intradermal nevi):
Basalioma, CLINIC (971)
Basaliomas, temple:
Basalioma, CLINIC (972)
Basalioma, superficial:
Basalioma, CLINIC (973)
Basalioma terebrans:
Basalioma, CLINIC (974)
Basalioma:
Basalioma, CLINIC (975)
Multiple basaliomas with pigment, syndrome of Gorlin:
Basalioma, CLINIC (976)
Superficial basalioma:
Basalioma, superficial, CLINIC (2829)Basalioma, superficial, CLINIC (2830)
Further examples of basalioma:
Histology:
The tumor consists of basophilic cells of high mitotic activity and roundish or oval shape. On the borders of tumorous nests there is usually palisading arrangement (exception: morphea-like basaliomas). The tumor is connected to the epidermis or adnexal epithelium. Artificial slits between the tumor and surrounding stroma are common.
Many variants: solid (nodular), superficial multicentric, cystic (cavities are caused by focal degeneration), adenoid, pigmented, invasive, morphea-like with sclerosis and infiltrative growth.
The peritumorus slits, basophilia and palisading are usually not present in invasive variants.
Basalioma fibroepithelial (fibroepithelioma of Pinkus) consists of multiple thin strands of tumorous epithelium which are connected to the epidermis. Stroma consists of fibrous tissue. Arteficial clefts between the epithelium and stroma are present. Peripheral palisading is focally present. Mitotic activity is usually low.
Pictures
Superficial basalioma:
Basalioma, superficial, HE 40x (2570)
Another case of superficial basalioma:
Basalioma, superficial, HE 40x (2571)
Large basalioma, infiltrating subcutis, bone and dura:
Basalioma, HE 20x (2521)Basalioma, HE 40x (2522)Basalioma, HE 40x (2544)
Large ulcerated basalioma, incomplete excision:
Basalioma, HE 5x (2609)
Basalioma:
Basalioma, HE 20x (3511)Basalioma, HE 40x (3512)
Basalioma:
Basalioma, HE 60x (10130)
Basalioma, adamantoid:
Basalioma, adamantoid, HE 60x (12024)
Basalioma:
Basalioma, HE 40x (12794)
Basalioma:
Basalioma, HE 40x (12795)
Basalioma:
Basalioma, HE 40x (12796)
Basalioma:
Basalioma, HE 40x (12797)Basalioma, PAS 40x (12798)
Basalioma, adenoid cystic:
Basalioma, adenoid cystic, HE 40x (12336)
Basalioma, adenoid cystic:
Basalioma, adenoid cystic, HE 40x (12650)
Basalioma, superficial:
Basalioma, superficial, HE 40x (12652)Basalioma, superficial, HE 40x (12654)Basalioma, superficial, HE 40x (12653)
Basalioma, superficial:
Basalioma, superficial, HE 60x (10131)Basalioma, superficial, HE 60x (10132)
Basalioma with desmoplastic features with solar degeneration of the corium:
Basalioma, desmoplastic, HE 20x (12337)
Basalioma fibroepithelial (of Pinkus):
Fibroepithelioma (basalioma) of Pinkus, HE 20x (2029)Fibroepithelioma (basalioma) of Pinkus, HE 40x (2030)
Another case of fibroepithelial bazalioma:
Fibroepithelioma (basalioma) of Pinkus, HE 20x (4943) [zoomify]
Another case of fibroepithelial bazalioma:
Fibroepithelioma (basalioma) of Pinkus, HE 20x (4426) [zoomify]
Another case of fibroepithelial bazalioma:
Fibroepithelioma (basalioma) of Pinkus, HE 20x (5233)
Another case of fibroepithelial bazalioma:
Fibroepithelioma (basalioma) of Pinkus, HE 20x (5393)
Another case of fibroepithelial bazalioma:
Fibroepithelioma (basalioma) of Pinkus, HE 60x (10277)
Another case:
Pinkus tumor, HE 40x (10935)
Another case:
Fibroepithelioma (basalioma) of Pinkus, HE 60x (14077)
Basalioma growing from the follicular epithelium:
Bazalioma, infundibular, HE 40x (3686)
Cystic basalioma:
Basalioma, cystic, HE 20x (4064)Basalioma, cystic, HE 40x (4065)
Cystic basalioma:
Basalioma, cystic, HE 20x (4427) [zoomify]
Another case:
Basalioma, HE 40x (4189)
Superficial basalioma combined with small intradermal melanocytic nevus:
Basalioma combined with melanocytic nevus, HE 40x (4292)
Tiny basalioma combined with seborrhoic keratosis:
Basalioma in combination with seborrhoic keratosis, HE 40x (5503)
Basalioma with focal squamoid differenciation:
Basalioma with focal squamoid metaplasia, HE 40x (4832) [zoomify]
Basalioma, sclerosing and infiltrating:
Basalioma, morpheiform, HE 40x (6117)
Sclerosing basalioma:
Basalioma, morpheiform, HE 60x (13816)
Spindle cell basalioma:
Spindle cell basalioma, HE 60x (13419)
Pale cell basalioma:
Clear cell basalioma, HE 60x (13427)
Pale cell basalioma:
Pale cell basalioma, HE 60x (13855)Pale cell basalioma, AE13 20x (13853)Pale cell basalioma, AE13 20x (13854)
Pleomorphic basalioma:
Pleomorphic basalioma, HE 60x (13905)
Basalioma, reexcision:
Basalioma, reexcision, HE 20x (5451)
Basalioma, reexcision:
Basalioma, reexcision, HE 60x (14036)
Basalioma, sclerodermiform, radiodermatitis:
Sclerosing basalioma under rentgendermatitis, HE 40x (12941)
Basalioma, mimicking sudoriferous ducts (HE, CEA):
Bazalioma, simulating sweat ducts, HE 60x (12799)Basalioma simulating sweat gland ducts, CEA 40x (12868)
Infiltrating basalioma of the skin near axilla,
metastasizing to the axillary lymphnode:
Basalioma, skin near axilla, HE 40x (6194)Basalioma metastasis to the lymphnode, HE 60x (6198)
Basalioma combined with intradermal melanocytic nevus:
Basalioma combined with melanocytic nevus, HE 60x (13702)Basalioma combined with melanocytic nevus, HE 60x (13701)
Basalioma combined with intradermal melanocytic nevus:
Bazalioma combined with intradermal nevus, HE 60x (13765)
Basalioma combined with seborrhoic keratosis:
Seborrhoic keratosis combined with basalioma, HE 20x (13924)
Introduction:
Clinical appearance correspond to that of basalioma, but prognosis is closer to squamous carcinoma.
Histology:
The tumor consist of two structures: basalioma and squamous cell carcinoma. Both are malignant (as opposed to basalima with squamous metaplasia.
Pictures
Polypoid metatypic carcinoma:
Polypoid basosquamous carcinoma, HE 20x (5996)
Metatypic carcinoma:
Metatypic carcinoma, HE 40x (12800)
Clinical signs:
Pictures
Destruction of the external ear in progressed squamous cell carcinoma:
Spinalioma, CLINIC (669)
Carcinoma spinocellulare:
Spinalioma, CLINIC (982)
Multiple foci of Bowen's disease, changing into squamous cell
carcinoma:
Spinalioma, CLINIC (983)
Carcinoma spinocellulare:
Spinalioma, CLINIC (984)
Carcinoma spinocellulare exulcerans:
Spinalioma, CLINIC (985)
Squamous cell carcinoma of the lower lip:
Squamous cell carcinoma of the lower lip, CLINIC (5551)Squamous cell carcinoma of the lower lip, CLINIC (5552)Squamous cell carcinoma of the lower lip, CLINIC (5553)
Squamous cell carcinoma of the lower lip:
Squamous cell carcinoma, lower lip, CLINIC (3343)
Carcinoma spinocellulare in lupo:
Spinalioma, CLINIC (986)
Carcinoma spinocellulare, metastases:
Spinalioma, CLINIC (987)
Carcinoma spinocellulare, retroauricular:
Spinalioma, CLINIC (988)
Carcinoma spinocellulare, penis:
Squamous cell carcinoma, Macro (3714)Squamous cell carcinoma, Macro (3715)Squamous cell carcinoma, Macro (3716)Squamous cell carcinoma, Macro (3717)Squamous cell carcinoma, Macro (3718)Squamous cell carcinoma, Macro (3719)Squamous cell carcinoma, Macro (3720)Squamous cell carcinoma, Macro (3721)
Squamous cell carcinoma of the lower lip, in addition solar elastosis with cysts and comedones in the skin (Syndrome of Favre Racouchot):
Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3722)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3723)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3724)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3725)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3726)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3727)Squamous cell carcinoma of the lower lip, solar elastosis, cysts and comedones (Favre Racouchot), Macro (3728)
Further examples of squamous cell carcinoma:
Histology:
The tumor consists of malignant cells, corresponding to the keratinocytes of the spinous layer of the epidermis: eosinophilic cytoplasm, intercellular bridges, focal keratinisation (in differentiated tumors).
Tumorous cells are polymorphous, there is (often high) mitotic activity, focal necroses, infiltrative growth. Horn pearls are the sign of good differentiation. Sometimes acantholysis is present.
Pictures
Squamous cell carcinoma:
Squamous cell carcinoma, HE 10x (2442)Squamous cell carcinoma, HE 40x (2443)Squamous cell carcinoma, HE 40x (2444)
Another case:
Squamous cell carcinoma, HE 20x (2739)Squamous cell carcinoma, HE 40x (2740)
Another case (next to osteomyelitic fistula; with
pseudoepitheliomatous hyperplasia):Squamous cell carcinoma, HE 20x (2507)Squamous cell carcinoma, HE 40x (2508)
Another case of squamous cell carcinoma:
Squamous cell carcinoma, well differentiated, HE 20x (4036)Squamous cell carcinoma, HE 40x (4037)
Another case of squamous cell carcinoma:
Squamous cell carcinoma of the skin, HE 40x (70284)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 20x (4985) [zoomify]
Squamous cell carcinoma, ear:
Squamous cell carcinoma, HE 40x (5005) [zoomify]
Squamous cell carcinoma, ear:
Squamous cell carcinoma, ear, HE 20x (5471)
Squamous cell carcinoma, tongue:
Squamous cell carcinoma, HE 40x (70258)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 40x (70285)
Another case:
Squamous cell carcinoma, HE 40x (6260)
Another case:
Squamous cell carcinoma, infiltrating, HE 20x (4699) [zoomify]
Well differentiated squamous cell carcinoma:
Squamous cell carcinoma, HE 20x (5291)
Infiltrating squamous cell carcinoma:
Squamous cell carcinoma, HE 60x (6338)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 40x (10135)Squamous cell carcinoma, HE 40x (10650)Squamous cell carcinoma, HE 40x (10651)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 40x (12981)Squamous cell carcinoma, HE 40x (12982)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 40x (12841)
Squamous cell carcinoma:
Myxoid carcinoma, HE 40x (12691)
Squamous cell carcinoma in an immunosuppressed patient:
Squamous cell carcinoma of an immunodeficient patient, HE 20x (4697) [zoomify]Squamous cell carcinoma of an immunodeficient patient, HE 20x (4698) [zoomify]
Squamous cell carcinoma with prominent acantholysis:
Squamous cell carcinoma, acantholytic, HE 20x (4034)Squamous cell carcinoma, acantholytic, HE 40x (4035)
Another example of acantholytic squamous cell carcinoma:
Squamous cell carcinoma, acantholytic, HE 40x (10924)Squamous cell carcinoma, acantholytic, AE13 40x (10922)Squamous cell carcinoma, acantholytic, Melan A 40x (10925)Squamous cell carcinoma, acantholytic, CD34 40x (10923)
Another example of acantholytic squamous cell carcinoma:
Squamous cell carcinoma, acantholytic, HE 40x (6123)
Another example of acantholytic squamous cell carcinoma:
Squamous cell carcinoma, acantholytic, AE13 20x (13961)Squamous cell carcinoma, acantholytic, HE 60x (13962)
Squamous cell carcinoma of the penis:
Squamous cell carcinoma, HE 40x (4067)
Squamous cell carcinoma of the ear:
Squamous cell carcinoma, ear, HE 20x (4997) [zoomify]
Infiltrating squamous cell carcinoma:
Squamous cell carcinoma, infiltrating, HE 40x (4302) [zoomify]
Squamous cell carcinoma with focal acantholysis:
Dediferentiated squamous cell carcinoma, HE 60x (10290)
Squamous cell carcinoma:
Squamous cell carcinoma, HE 40x (13255)
Undifferentiated squamous cell carcinoma:
Squamous cell carcinoma, low differentiated, HE 60x (12126)
Squamous cell carcinoma, lip:
Squamous cell carcinoma, lip, HE 40x (12538)
Squamous cell carcinoma, lip:
DG, HE 40x (75928)
Squamous cell carcinoma of the tongue, initial situation in
diagnostic biopsy and condition after 4 months chemotherapy, when
only small foci of granulomatous reaction after necrosis of tumorous
cells is present:
Squamous cell carcinoma, tongue, HE 40x (5959)Squamous cell carcinoma, tongue, after chemotherapy, HE 40x (5960)
Reexcision of a low differentiated squamous cell carcinoma
in an immunosupressed patient:
Squamous cell carcinoma in immunosuppressed patient, HE 20x (4726) [zoomify]Squamous cell carcinoma at immunosuppressed patient, HE 20x (4731) [zoomify]Squamous cell carcinoma, low differentiated, AE13 20x (4761)
Low differentiated squamous cell carcinoma:
Dedifferentiated squamous cell carcinoma, HE 40x (10151)Dediferentiated squamous cell carcinoma, HE 40x (10291)
Squamous cell carcinoma, external ear:
Squamous cell carcinoma, HE 20x (13788)
Squamous cell carcinoma, xeroderma pigmentosum, child 6 y:
Squamous cell carcinoma, lip, xeroderma pigmentosum, HE 60x (14090)
Low differentiated squamous cell carcinoma:
Squamous cell carcinoma, low differentiated, HE 20x (4771)Squamous cell carcinoma, low differentiated, AE13 20x (4761)
Low differentiated squamous cell carcinoma:
Squamous cell carcinoma, low differentiated, HE 60x (6407)
Squamous cell carcinoma, spindle cells:
Fusicellular squamous cell carcinoma, HE 60x (13865)
Epidermal cyst with squamous cell carcinoma:
Squamous cell carcinoma within an infundibular cyst, HE 40x (4836) [zoomify]
Squamous cell carcinoma, high grade:
Squamous cell carcinoma, high grade, HE 60x (14088)Squamous cell carcinoma, high grade, AE13 20x (14087)
Squamous cell carcinoma, perineural spread, HE 60x (14089)
Metastasis of squamous cell carcinoma of the dermis:
Squamous cell carcinoma, metastasis, HE 20x (6166)
Clinical signs:
Histology:
Irregular papillomatosis, acanthosis, well differentiated squamous epithelium, no significant cellular atypia. Mitotic activity is low. Keratin filled sinuses are formed. Focal parakeratosis, inflammation with the presence of neutrophils and eosinophils is present. The diagnosis is usually difficult, the tumor does not look malignant, repeated excisinos are often necessary to establish the diagnosis.
Pictures
Verrucous carcinoma:
Verrucous carcinoma, HE 40x (10069)
Clinical signs:
Histology:
Large condyloma, epithelial proliferation and dysplasia.
Pictures
Giant condyloma:
Condylomata giant of Buschke Lowenstein, HE 5x (1948)Condylomata giant of Buschke Lowenstein, HE 40x (1947)
Another case:
Condyloma giant of Buschke Lowenstein, HE 40x (13220)
Clinical signs:
Etiology:
Most cases are associated with HPV infection.
Histology:
Tumor consists of small keratinocytes. High mitotic activity.
Pictures
Basaloid carcinoma, perianal region:
Basaloid carcinoma (cloacogenic), HE 60x (13870)
Clinical signs:
Histology:
Islands of roundish epithelial cells within the dense lymphocytic infiltrate. No keratinization. Histologically resembles nasopharyngeal carcinoma.
Pictures
Lymphoepithelioma-like carcinoma, perianal skin:
Lymphoepithelioma-like carcinoma, HE 40x (12911)
Lymphoepithelioma-like carcinoma:
Lymphoepithelioma-like carcinoma, HE 60x (13779)