Clinical signs:
Histology:
The whole lymph node is infiltrated by T lymphocytes. On the periphery of the lymph node small follicles persist. The infiltrate consists of T cells of middle size; larger elements are present as well. These cells have several large nucleoli and broad cytoplasm. Focal necroses. T cells enter into the wall of epitheloid venules. High mitotic activity.
Immunoprofile: CD3+, CD45RO+, CD43+, CD4+, CD8+. Frequent cells are CD30+, ALK-, CD20-, CD79a-, CD10-, CD56-, CD138-, CD23 positive in dendritic cells, LMP-1-, granzyme B+, BerH9-, no t(2;5) translocation, disperse CD68+ histiocytes. KI67: 50 – 60%.
Conclusion:
Peripheral T lymphoma, unspecified, Murphy stage III.
Therapy:
She received chemotherapy according to ALCL 99, HR arm + 12 months OF vinblastine maintenance therapy, OS/EFS 63 months now (4/2010).
Primary T lymphoma, not otherwise specified, HE 60x (74085)