Peripheral T lymphoma, unspecified

3  Atlas of Rare Lymphomas

3.5  Peripheral T lymphoma, unspecified

Clinical signs:


The whole lymph node is infiltrated by T lymphocytes. On the periphery of the lymph node small follicles persist. The infiltrate consists of T cells of middle size; larger elements are present as well. These cells have several large nucleoli and broad cytoplasm. Focal necroses. T cells enter into the wall of epitheloid venules. High mitotic activity.

Immunoprofile: CD3+, CD45RO+, CD43+, CD4+, CD8+. Frequent cells are CD30+, ALK-, CD20-, CD79a-, CD10-, CD56-, CD138-, CD23 positive in dendritic cells, LMP-1-, granzyme B+, BerH9-, no t(2;5) translocation, disperse CD68+ histiocytes. KI67: 50 – 60%.


Peripheral T lymphoma, unspecified, Murphy stage III.


She received chemotherapy according to ALCL 99, HR arm + 12 months OF vinblastine maintenance therapy, OS/EFS 63 months now (4/2010).


T lymphoma:
Primary T lymphoma, not otherwise specified, HE 60x (74085)

Primary T lymphoma, not otherwise specified, CD3 60x (74121)

Primary T lymphoma, not otherwise specified, CD43 60x (74122)

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