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Atlas of Neonatal Pathology
Marta Ježová, Josef Feit
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+ Neonatal pathology
+ Basic terms and classification of newborn infants
+ The Apgar score
+ Classification of newborn infants by weight and gestation
+ Pathology of gestation length
+ Prematurity
+ Postmaturity (Clifford syndrome)
+ Growth and developement
+ Intrauterine growth retardation (IUGR), small for gestational age infant (SGA)
+ Large for gestational age infant (LGA)
+ Physical maturity
+ Pathology of prematurity
+ Gross appearance of premature infant
+ Difficulties in maintaining homeostasis
+ Thermoregulation
+ Hypoglycemia
+ Hyperbilirubinemia
+ Fluids and electrolytes
+ Apnea of prematurity
+ Anemia of prematurity
+ Hyaline membrane disease (HMD)
+ Necrotizing enterocolitis (NEC)
+ Intraventricular hemorrhage (IVH)
+ Periventricular leukomalacia (PVL)
+ Patent ductus arteriosus (PDA)
+ Iatrogenic diseases and damage
+ Respiratory system
+ Injuries caused by endotracheal intubation
+ Pulmonary air leak
+ Bronchopulmonary dysplasia (BPD)
+ Retinopathy of prematurity (ROP)
+ Cardiovascular system
+ Total parenteral nutrition associated hepatic damage
+ Infections
+ Viability, survivability and long term sequelae of prematurity
+ Viability
+ Survivability in prematurity
+ Severe long term sequelae in babies born prematurely
+ Birth asphyxia
+ Hypoxic-ischemic encephalopathy (HIE)
+ Meconium aspiration syndrome (MAS)
+ Persistent pulmonary hypertension of the newborn (persistent fetal circulation)
+ Birth trauma
+ Extracranial lesions
+ Soft tissus injuries
+ Intraabdominal injuries
+ Peripheral and cranial nerve injuries
+ Bone injuries
+ Cranial trauma
+ Perinatal infection
+ Intrauterine infections (TORCH group)
+ Sepsis neonatorum
+ Blenorrhea neonatorum
+ HIV infection
+ Stillbirth and perinatal mortality
+ Stillbirth
+ Perinatal mortality
+ Neonatal pathology nonrelated to prematurity, birth asphyxia or infection
+ Congenital anomalies in liveborn infants
+ Kernicterus
+ Hemorrhagic disease of the newborn
+ Spontenous gastric perforation in a neonate
The Apgar score
Introduction

Developed by Dr. Virginia Apgar, an anesthesiologist, in 1953 for the purpose of providing a simple, clear classification or grading of newborn infants which can be used as a basis for discussion and comparison of the results of obstetric practices, types of maternal pain relief and the effects of resuscitation.

Classification
Table: Apgar score

Body

0

1

2

Heart action

None

Under 100/min

Over 100/min

Breathing

None

Slow, irregular

Regular, cry

Muscle tone

None

Weak

Normal

Reaction to irritation

None

Grimase

Cry

Skin color

General cyanosis and paleness

Acrocyanosis

Pink

The scoring system comprises 5 signs: heart rate, respiratory effort, muscle tone, reflex irritability and color, each of which is given zero, one or two points. The total score ranges from zero to ten points.

The baby is scored at 1, 5 and 10 minutes after birth.

A score of 7 – 10 is considered normal, 4 – 7 intermediate, 0 – 3 poor; the infant requires immediate resuscitation

Clinical signs

The Apgar score significance

Rapid standardized assassement of the clinical status of the newborn infant and the need for prompt resuscitation A change in score is a useful index of the response to resuscitation. On the other hand the Apgar score has limitations. It is affected by gestational age, maternal medication, resuscitation, congenital anomalies, infections and trauma.

Apgar score in preterm infants

Signs as tone, color or reflex irritability paritally depend on the physiologic maturity of the infant. The healthy preterm infants may receive a low score only because of immaturity.

Apgar score and asphyxia

In is innapropriate to use an Apgar score alone to establish the diagnosis of asphyxia. Other factors such as abnormalities in umbilical arterial blood gases, clinical cerebral function, placental pathology and multisystem organ dysfunction need to be considered.

Apgar score and prediction of neurological outcome in the term infant

A low 1-minute Apgar score alone does not correlate with the infants future outcome. An Apgar score of 0 to 3 at 5 minutes may correlate with neonatal mortality but alone does not predict later neurologic dysfunction. (75% of children with cerebral palsy have normal scores at 5 minutes). The risk of poor neurological outcome increases when the Apgar is 3 or less in 10, 15 and 20 minutes.