Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Superficial spreading melanoma, SSM
Histology

Malignant, atypical melanocytes are present in all layers of the epidermis (scatter). Nuclei are irregular, chromatin is clumped, nucleoli are prominent. Some mitotic activity is usually present.

The tumor infiltrates papillary dermis and spreads horizontally: thin, asymmetric melanocytic proliferation, unsharp borders, irregular distribution of melanin.

Dermis shows fibrosis, variable lymphocytic infiltrate and melanophages.

SSM (13202)

SSM (10829)

Pictures

Superficial spreading melanoma: Melanoma, superficial spreading (SSM), HE 40x (2296) Melanoma, superficial spreading (SSM), HE 40x (2297)

Another case: Superficial spreading melanoma, HE 60x (6281)

Another case: Superficial spreading melanoma, HE 40x (4155)

Another case: Superficial spreading melanoma, HE 40x (2446) Superficial spreading melanoma, elastic fibres 40x (2445)

Another case: Superficial spreading melanoma, HE 40x (2330)

Another case: Superficial spreading melanoma, HE 40x (2331)

Another case: Intraepidermal melanoma, HE 40x (3586)

Another case: Superficial spreading melanoma, HE 40x (2741) Superficial spreading melanoma, Ki67 40x (2742)

Another case: Melanoma, HE 60x (12914)

Another case, proliferation marker Ki67: Superficial spreading melanoma, Ki67 40x (2744)

Another case, with small subepidermal vesicles: Superficial spreading melanoma, HE 20x (3506) Superficial spreading melanoma, HE 40x (3507)

Small melanoma: Superficial spreading melanoma, SSM, HE 20x (4807) Superficial spreading melanoma, SSM, HMB45 20x (4808)

SSM on (slightly) sun damaged skin: Superficial spreading melanoma, SSM, HE 20x (5416)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (10827)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (10829)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (12703)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (12472)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (12294)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 40x (13202)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 60x (12742)

Superficial spreading melanoma: Superficial spreading melanoma, SSM, HE 40x (10938)

Superficial spreading melanoma, nodularity: Superficial spreading melanoma, vertical growth, HE 60x (14021)

Melanoma, SSM, with baloon melanocytes: Balloon cell melanoma, HE 60x (13632)

Superficial spreading melanoma, vertical growth