Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Nodular melanoma
Histology

Large, clearly malignant melanocytic tumor reaching into the deep dermis. Formed by large tumorous nodule with only minimal signs of epidermal invasion and superficial lateral spread.

Prominent melanocytic atypia, usually high mitotic activity. Differential diagnosis against melanoma metastasis may be difficult.

Nodular melanoma (3633)

Nodular melanoma (3632)

Nodular melanoma (13198)

Nodular melanoma (6302)

Nodular melanoma (14065)

Nodular melanoma (13739)

Pictures

Nodular melanoma: Melanoma, nodular, HE 5x (2526) Melanoma, HE 10x (2713) Melanoma, nodular, HE 40x (2525) Melanoma, HE 40x (2714)

Another case: Nodular melanoma, HE 20x (2712)

Another case: Nodular melanoma, HE 20x (3619) Nodular melanoma, HE 40x (3620) Nodular melanoma, Ki67 40x (3621) Nodular melanoma, Melan A 40x (3606)

Another case of ulcerating nodular melanoma: Nodular melanoma, ulcerated, HE 40x (3633) Nodular melanoma, ulcerated, S100 20x (3632) Nodular melanoma, Ki67 20x (3674)

Part of the large nodular melanoma with mitotic activity, production of melanin and cellular and nuclear polymorphism: Nodular melanoma, large, HE 40x (4186)

Nodular melanoma with no lymphocytic infiltrate, rather symmetric, of regular melanocytes, with slight mitotic activity, without maturation; further metastasis to the axillary lymphnode after three years (male, 26 years, forearm): Melanoma, nodular, HE 60x (6302) Melanoma metastasis, axillary lymphnode, HE 60x (6303)

Nodular melanoma, traumatized, high mitotic activity: Nodular melanoma, HE 60x (6413) Nodular melanoma, Melan A 40x (6412)

Nodular melanoma: Nodular melanoma, HE 40x (13198)

Nodular melanoma: Nodular melanoma, HE 40x (13199)

Nodular melanoma: Nodular melanoma, HE 60x (6438)

Nodular melanoma: Nodular melanoma, HE 60x (10828)

Nodular melanoma: Nodular melanoma, HE 40x (12471)

Nodular melanoma: Nodular melanoma, HE 60x (14008)

Nodular melanoma: Nodular melanoma, HE 60x (14009)

Flat nodular melanoma with atypical melanocytes and mitotic activity: Nodular melanoma, mitoses, atypia, HE 40x (12702)

Nodular melanoma, very high mitotic activity: Nodular melanoma, high mitotic activity, HE 60x (13739)

Nodular melanoma, spindle melanocytes: Spindle cell nodular melanoma, HE 60x (13430) Nodular melanoma, spindle melanocytes, Melan A 20x (13425)

Heavily pigmented melanoma (equinne type?): Malignant melanoma, equinne type, HE 60x (13674)

Recurrence of nodular melanoma: Recurrent nodular melanoma, HE 60x (14065) Recurrent nodular melanoma, HE 60x (14066)

Nevoid melanoma