Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Pleomorphic medium-sized and large T cell lymphoma (HTLV-1 +/-)
Clinical signs
  • solitary or multiple nodular lesions
Histology

Medium sized or large pleomorphic cells with multishaped nuclei. Small reactive lymphocytes, eosinophils and plasma cells. Significant epidermotropism with formation of intraepidermal microabscesses in the HTLV-1 positive leukemic form (adult T-cell lymphoma/leukemia).

Immunophenotype and genetic features:

  • CD30- variants
  • CD2+, CD3+, CD5+, CD7-, CD4+, CD8+ (rare cases)
  • clonal rearrangement of TCR genes
Pictures

Pleomorphic medium sized and large T cell lymphoma: Pleiomorphic T cell lymphoma, medium to large cells, HE 40x (2245)

Another case: Pleiomorphic T cell lymphoma, medium to large cells, HE 40x (2247) Pleomorphic medium to large T cell lymphoma, HE 100x (2500) Pleiomorphic T cell lymphoma, medium to large cells, CD30 40x (2246)

Another case: Pleiomorphic T cell lymphoma, medium to large cells, HE 40x (2250) Pleiomorphic T cell lymphoma, medium to large cells, HE 40x (2251) Pleomorphic medium to large T cell lymphoma, HE 100x (2501) Pleiomorphic T cell lymphoma, medium to large cells, CD30 40x (2248) Pleiomorphic T cell lymphoma, medium to large cells, CD30 40x (2249)

Another case: Pleomorphic medium to large T cell lymphoma, HE 20x (2503) Pleiomorphic T cell lymphoma, medium to large cells, HE 40x (2252) Pleomorphic medium to large T cell lymphoma, HE 100x (2502) Pleomorphic medium to large T cell lymphoma, CD30 40x (2432)

Another case: Pleiomorphic T cell lymphoma, medium to large cells (PTCL), HE 20x (4583) Pleiomorphic T cell lymphoma, medium to large cells (PTCL), CD3 20x (4579) Pleiomorphic T cell lymphoma, medium to large cells (PTCL), CD30 20x (4580) Pleiomorphic T cell lymphoma, medium to large cells (PTCL), CD4 20x (4581) Pleiomorphic T cell lymphoma, medium to large cells (PTCL), CD8 20x (4582) Pleiomorphic T cell lymphoma, medium to large cells (PTCL), Ki67 20x (4584)

Another case: Pleiomorphic T cell lymphoma, medium to large cells (PTCL), HE 20x (4653)

Another case: Pleiomorphic T cell lymphoma, medium to large cells (PTCL), HE 20x (4654)