Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Juvenile granulomatous cutaneous T cell lymphoma
Introduction

Provisional group of low grade, slowly progressive cutaneous T cell lymphoma with distinct clinical features and associated with high risk of development of systemic lymphoma.

Clinical signs
  • patchy or nodular, localized or disseminated skin lesions
  • age: childhood or young adults (4 – 23 years, median 13)
  • slow progression
  • after 20 years nodal Hodgkin's disease (nodular sclerosis) or extracutaneous large cell anaplastic Ki-1+ lymphoma in 50% of cases
Histology

Patchy or nodular infiltrate consisting of histiocytes, epithelioid cells and a few multinucleated giant cells with a variable admixture of small well differentiated lymphocytes.

Immunophenotype and genetic features:

  • clonal rearrangement for TCR genes

Juvenile granulomatous cutaneous T cell lymphoma (2467)