Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
×
+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Behcet's disease
Clinical signs
  • affects especially young adults
  • painful lesions of the oral mucosa (almost constant finding)
  • genital ulcerations
  • ocular lesions (uveitis, hypopyon, iridocyclitis)
  • skin lesions:
    • trombophlebitis
    • erythema nodosum-like lesions
    • papulopustular lesions
    • sterile pustules after minor trauma
    • lesions resembling Sweet's syndrome
  • synovitis, meningoencephalitis
Histology

Histology is quite variable.

Aphtous lesions show epithelial defect and (sometimes deep) perivascular and diffuse inflammatory infiltrate with neutrophils.

Skin pustules show deep neutrophilic infiltrate.

Erythema nodosum-like lesions show early lymphocytic infiltration within the fat and deep dermis; later many neutrophils are present.

Vasculitis and other changes are being described as well

Pictures

Behcet's disease, skin pustule and oral mucosa ulceration: Behcet's disease, HE 40x (3611) Behcet's disease, oral mucosa, HE 40x (3612)

Behcet's disease, perifollicular lesion: Behcet's disease, HE 20x (5122)

Flat ulceration with dense mixed inflammatory infiltrate at the base of epithelial defect: Behcet's disease, HE 20x (4314)

Pathergic reaction: Pathergic reaction, HE 20x (4574)

Behcet's disease: Behcet's disease, HE 20x (5083)