Fetopathology and developmental pathology of the embryo and fetus: Subacute necrotizing funisitis

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+ Umbilical cord inflammation

+ Acute funisitis

+ Subacute necrotizing funisitis

+ Miscellaneous rare cord lesions

Subacute necrotizing funisitis

Introduction

Subacute or chronic inflammation of the umbilical cord associated with high perinatal mortality.

Etiology

Treponema pallidum, herpes simplex virus, other organisms with low virulence such as Mycoplasma are also suspected.

Macroscopic appearance

Thickened whitish umbilical vessels resembling macaroni.

Histology

Necrotizing basophilic exudate accumulates in concentric perivascular rings or crescents. The exudate may become calcified.