Pathology
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Fetopathology and developmental pathology of the embryo and fetus
Marta Ježová, Josef Feit et al.
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+ Atlas of fetal pathology
Rubella
Introduction

Highly teratogenic agent, the risk of fetal damage is 60% and higher, and is extremly dangerous in case the infection occures before 16th w.g. The risk decreases as the pregnancy continues to the later stages.

Macroscopic appearance

The infection results in a large variety of congenital malformations: triad of congenital heart defects (patent ductus arteriosus, hypoplasia or stenosis of the pulmonary artery, septal defects, tetralogy of Fallot), deafness and blindness.

Histology

Necrosis of vascular endothelial cells, necrotic foci in the vicinity of supposed hematogenous spread in fetal tissues and the placenta.