Fetopathology and developmental pathology of the embryo and fetus: Cleft lip and palate

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Cleft lip and palate

Classification

isolated cleft lip — cheiloschisis
isolated cleft palate — palatoschisis, veloschisis, uvula bifida
complex cleft — cheilognathopalatoschisis
submucouse cleft palatum — mucosal cover is developed
central cleft lip is less frequent (associated with holoprosencephalia)
oblique cleft leads from the mouth to the orbita

Clinical signs

may be unilateral or bilateral
develop when the maxilar and mandibular branchial arch do not connect
frequent is association with the amniotic band syndrome
most frequent congenital malformation of the oral cavity, incidence 1 : 950
symptomes:
- disorders of sucking, swallowing, phonation
- frequent aspiration of the food
- reccurent otitides and pneumonias

Pictures

Median cleft lip: Bilateral cleft lip, trisomy 13, Macro, autopsy (72106)

Cleft lip and palate: Cheilopalatoschisis, Macro, autopsy (73060)

Cheiloschisis, cheilognathopalatoschisis: Palatoschisis, Macro, autopsy (72391)

Holoprocencephalia, cleft: Holoprosencephaly, Macro, autopsy (72104)

Cheilognathopalatoschisis: Cheilognathopalatoschisis, Macro, autopsy (74002) Cheilognathopalatoschisis, Macro, autopsy (74003)

Cheilognathopalatoschisis: Cheilognathopalatoschisis, Macro, autopsy (74004) Cheilognathopalatoschisis, Macro, autopsy (74005)

Cleft palate: Cleft palate, Macro, autopsy (74432) Cleft palate, Macro, autopsy (74433)