Fetopathology and developmental pathology of the embryo and fetus: Neuroepithelial cyst

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Neuroepithelial cyst

Etiology

Developemental cyst lined with neuroepithelium (ependymal, choroid plexus cells or mix of both). An outer layer of glial cells may be present.

Macroscopic appearance

smooth thin walled unilocular or septate cyst containing clear fluid
most often found supratentorial in the midline (interhemispheric cysts), but inftratentorial or intraventricular locations were also described
interhemispheric cysts associated with complete or partial corpus callosum agenesis have been reported

Neuroepithelial cyst (72969)

Histology

Ependymal cells (ciliated), choriod plexus cells, glial elements, connective tissue.

Case study

Intracranial cyst

Marta Ježová

History

31 – year woman, second gravidity.

Prenatal ultrasound examination (23 weeks): a cyst 20×13 mm between the cerebellum and the left cereberal hemisphere. Arachnoid origin ot the cyst was supposed. Ventricular system was normal.

Fetal karyotype: 46 XX

Final diagnosis (based on histology and imunohistochemical staining): intehemispheric neuroepithelial (glioependymal) cyst.

Macroscopic appearance

24 – week female fetus.

Large thin walled cyst 25 mm in diameter was detected supratentorial in the midline. The cyst had no continuity with the leptomeninges and contained clear fluid.

Pictures

Intracranial cyst, UZ video: Neuroepithelial cyst, Ultrasound, video (72950)

Intracranial cyst, autopsy: Neuroepithelial cyst, Macro, autopsy (72969)

Wall of the cyst, S100 protein positive: Neuroepithelial cyst, fetus, HE 40x (72990) Neuroepithelial cyst, fetus, HE 40x (72992) Neuroepithelial cyst, fetus, S100 40x (72991) Neuroepithelial cyst, fetus, EMA 40x (72989)