Fetopathology and developmental pathology of the embryo and fetus: Lobar sequestration

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Lobar sequestration

Macroscopic appearance

unusual condition, characterized by separation of a focus of pulmonary tissue from the tracheobronchial tree
extralobar and intralobar types can be distinguished:
- Extralobar sequestration: mass of pulmonary tissue is located outside the pleura and is not connected to the tracheobronchial tree. Left hemithorax is affected more often. Histology corresponds to immature pulmonary tissue with dilated bronchi.
- Intralobar sequestration: this condition is mentioned just for the sake of completeness, because it does not occur in prenatal or perinatal period. Affected are adult persons suffering of repeated bronchopulmonary infections. Intralobar sequestration is a part of pulmonary tissue covered by pleura, with systemic blood supply without any evident connection to the bronchi, often with acute or chronic inflammation.