Pathology
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Atlas of Neonatal Pathology
Marta Ježová, Josef Feit
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+ Neonatal pathology
+ Basic terms and classification of newborn infants
+ The Apgar score
+ Classification of newborn infants by weight and gestation
+ Pathology of gestation length
+ Prematurity
+ Postmaturity (Clifford syndrome)
+ Growth and developement
+ Intrauterine growth retardation (IUGR), small for gestational age infant (SGA)
+ Large for gestational age infant (LGA)
+ Physical maturity
+ Pathology of prematurity
+ Gross appearance of premature infant
+ Difficulties in maintaining homeostasis
+ Thermoregulation
+ Hypoglycemia
+ Hyperbilirubinemia
+ Fluids and electrolytes
+ Apnea of prematurity
+ Anemia of prematurity
+ Hyaline membrane disease (HMD)
+ Necrotizing enterocolitis (NEC)
+ Intraventricular hemorrhage (IVH)
+ Periventricular leukomalacia (PVL)
+ Patent ductus arteriosus (PDA)
+ Iatrogenic diseases and damage
+ Respiratory system
+ Injuries caused by endotracheal intubation
+ Pulmonary air leak
+ Bronchopulmonary dysplasia (BPD)
+ Retinopathy of prematurity (ROP)
+ Cardiovascular system
+ Total parenteral nutrition associated hepatic damage
+ Infections
+ Viability, survivability and long term sequelae of prematurity
+ Viability
+ Survivability in prematurity
+ Severe long term sequelae in babies born prematurely
+ Birth asphyxia
+ Hypoxic-ischemic encephalopathy (HIE)
+ Meconium aspiration syndrome (MAS)
+ Persistent pulmonary hypertension of the newborn (persistent fetal circulation)
+ Birth trauma
+ Extracranial lesions
+ Soft tissus injuries
+ Intraabdominal injuries
+ Peripheral and cranial nerve injuries
+ Bone injuries
+ Cranial trauma
+ Perinatal infection
+ Intrauterine infections (TORCH group)
+ Sepsis neonatorum
+ Blenorrhea neonatorum
+ HIV infection
+ Stillbirth and perinatal mortality
+ Stillbirth
+ Perinatal mortality
+ Neonatal pathology nonrelated to prematurity, birth asphyxia or infection
+ Congenital anomalies in liveborn infants
+ Kernicterus
+ Hemorrhagic disease of the newborn
+ Spontenous gastric perforation in a neonate
Cardiovascular system
Clinical signs

Complicacions related to vascular cannulation

Insertion of both umbilical arterial catheter and umbilical venous catheter is routinely performed after birth or several days after in the neonate. Umbilical venous catheter is preferred when immediate vascular access is required. Cannulation of umbilical vein has more frequent complications. Catheters are also insterted into subclavian vein. With use of vascular cannulation there is a general risk of accidental dislogement, hemorrhage, endothelial trauma and associated thrombosis, thrombemboli and infection by bacteria and fungi colonizing the lines. Otherwise a small trombus adherent to the tip of the catheter is quite common as well as small mural thrombi.

More serious complications are:

  • Umbilical artery  —  massive aortic thrombosis, mesenteric, renal and limb arteries thrombosis resulting in visceral infarction or necrotizing enterocolitis, lower limb and perineum gangrene, gangrene of toes with thrombemboli, vasospasm, hematuria, renal insufficiency, transient increse in blood pressure
  • Umbilical vein  —  thrombosis of portal vein branches and hepatic necrosis, portal hypertension
  • Systemic veins  —  catheter related infecions and central sepsis, vena cava obstruction, cardia arrythmias, pleural and pericardial effusiont, perforation of myocardium (rare)
Pictures