Atlas of dermatopathology: T~zone lymphoma, Lennert and Mohri

+ Introduction

+ Using this atlas

+ Conditions of using this atlas

+ Technical notes

+ Hardware

+ Software

+ How to use the atlas

+ Navigating through the text pages

+ Controlling the pictures

+ Logos and labels

+ What will you need to use the atlas

+ Bugs, problems

+ Netscape

+ Microsoft Internet Explorer

+ Some other Internet resources concerning dermatopathology and pathology

+ Literature

+ The literature used to prepare this atlas

+ Publications concerning the atlas

+ Support

+ Skin biopsy

+ Examples of special stainings

+ Polarization

+ Immunofluorescence

+ Direct Immunofluorescence

+ Pemphigus vulgaris and its variants (immunofluorescence)

+ Bullous pemphigoid (immunofluorescence)

+ Pemphigoid (herpes) gestationis (immunofluorescence)

+ Dermatitis herpetiformis Duhring (immunofluorescence)

+ Lupus erythematosus (SLE, CDE a SCLE); (immunofluorescence)

+ Sharp's syndrome

+ Lichen ruber planus (immunofluorescence)

+ Vasculitis, immunocomplex type (immunofluorescence)

+ Porphyria cutanea tarda (PCT) and hepatopathies (immunofluorescence)

+ Indirect immunofluorescence

+ Antinuclear antibodies (ANA)

+ Endomysial antibodies

+ Antibodies aganist neutrophilic cytoplasm (ANCA)

+ Non-tumorous skin diseases

+ Diseases of the Epidermis

+ Ichthyosis

+ Ichthyosis vulgaris

+ Ichthyosis lamellaris

+ X-linked ichthyosis

+ Epidermolytic hyperkeratosis

+ Ichthyosis acquisita

+ Keratosis palmoplantaris, palmoplantar keratoderma

+ Ectodermal dysplasia

+ Psoriasis

+ Psoriatic erytroderma

+ Palmoplantar psoriasis and palmoplantar pustulosis

+ Generalized pustular psoriasis of Zumbusch

+ Lingua geographica

+ Psoriatiform keratosis

+ Infantile acropustulosis

+ Darier's disease

+ Porokeratosis

+ Acrokeratoelastoidosis

+ Pityriasis rubra pilaris

+ Glucagonoma syndrome

+ Acrodermatitis enteropathica

+ Blistering diseases

+ Classification

+ Impetigo

+ Staphylococcal scalded skin syndrome

+ Subcorneal pustular dermatosis of Sneddon-Wilkinson

+ Peeling skin syndrome

+ Acute generalized exanthematous pustulosis (AGEP)

+ Pemphigus vulgaris

+ Pemphigus vegetans

+ Neonatal pemphigus

+ Pemphigus erythematosus Senear-Usher

+ Pemphigus foliaceus

+ Paraneoplastic pemphigus

+ IgA pemphigus

+ Hailey-Hailey (Familial benign pemphigus)

+ Transient acantholytic dermatosis (of Grover)

+ Herpes zoster, varicella, Herpes simplex

+ Herpes simplex

+ Eczema herpeticatum Kaposi Juliusberg

+ Herpes zoster, varicella

+ Bullous pemphigoid

+ Cicatricial pemphigoid

+ Pemphigoid (herpes) gestationis

+ Porphyria cutanea tarda

+ Pseudoporphyria

+ Bulla in diabetes

+ Dermatitis herpetiformis Duhring

+ IgA linear dermatosis

+ Erythema multiforme

+ Toxic epidermal necrolysis of Lyell

+ Stevens-Johnson syndrome

+ Graft versus host reaction

+ Epidermolysis bullosa

+ Epidermolysis bullosa dystrophica

+ Epidermolysis bullosa acquisita

+ Artifical clefts in basaliomas

+ Allergic contact dermatitis, acute

+ Dyshidrotic dermatitis

+ Eczema atopicum (dermatitis atopica)

+ Subacute and chronic (eczem) dermatitis

+ Microbial eczema

+ Granuloma gluteale infantum

+ Toxic contact (irritative) dermatitis, acute

+ Toxic contact (irritative) dermatitis, chronic

+ Seborrhoic dermatitis

+ Pityriasis amiantacea

+ Changes caused by rubbing, scratching and pressure

+ Lichen simplex

+ Strophulus

+ Prurigo gestationis

+ Prurigo nodularis

+ Prurigo senilis

+ Atopic dermatitis

+ Picker's nodule

+ Excoriation

+ Chronic pressure (hip)

+ Amputation stump

+ Granuloma fissuratum

+ Pressure necrosis

+ Tyloma, callus

+ Clavus

+ Morsicatio buccarum

+ Perivascular infiltration of upper dermis

+ Pityriasis lichenoides Mucha Habermann

+ Pityriasis lichenoides acuta

+ Pityriasis lichenoides chronica

+ Pityriasis rosea Gibert

+ Diffuse infiltration infiltration of the upper dermis

+ Lichen ruber planus

+ Lichen verrucosus (hypertrophicus)

+ Lichen ruber, vesicular

+ Lichen planopilaris

+ Lichen planus like keratosis (benign lichenoid keratosis)

+ Lichenoid drug reaction

+ Lichen nitidus

+ Lichen striatus

+ Erythema dyschromicum perstans

+ Poikiloderma Rothmund Thomson

+ Poikiloderma vasculare atrophicans

+ Infiltration of the upper and deep corium

+ Erythema annulare centrifugum (erythema figuratum)

+ Erythema gyratum repens

+ Lymphocytic infiltrate of Jessner-Kanof

+ Urticaria

+ Pruritic urticarial papules and plaques of pregnancy (PUPPP)

+ Well's syndrome

+ Hypereosinophilic syndrome

+ Granuloma faciale (eosinophilicum)

+ Erythema elevatum diutinum

+ Sweet's syndrome

+ Behcet's disease

+ Pyoderma gangrenosum

+ Granulomatous processes of deeper corium

+ Granuloma annulare

+ Granuloma annulare, deep

+ Granuloma multiforme

+ Annular elastolytic granuloma

+ Necrobiosis lipoidica

+ Granulomatosis disciformis Miescher

+ Rheumatoid nodule

+ Chondrodermatitis nodularis chronica helicis

+ Polychondritis recurrens

+ Sarcoidosis

+ Erythema induratum Bazin

+ Foreign body granulomas

+ Silicone granuloma

+ Cat scratch disease

+ Cheilitis granulomatosa Miescher Melkerson Rosenthal

+ Intersticial granulomatous dermatitis

+ Crohn's disease, skin changes

+ Connective tissue disorders

+ Lupus erythematosus

+ Lupus erythematodes, acute

+ Acute neonatal lupus erythematodes

+ Lupus erythematodes, subacute

+ Lupus erythematodes, chronic

+ Lupus erythematodes profundus

+ Dermatomyositis

+ Osteoarthritis, Heberden nodes

+ Scleroderma, morphea

+ Diffuse scleroderma

+ Localized scleroderma, morphea

+ Lichen sclerosus et atrophicus

+ Pachydermoperiostosis

+ Eosinophilic fasciitis

+ Fibromatosis

+ Infantile digital fibromatosis (inclusion body fibromatosis)

+ Intravascular fasciitis

+ Desmoid type fibromatosis, desmoid

+ Striae distensae

+ Skin graft

+ Perforating collagenosis

+ Disorders of elastic fibres

+ Anetoderma

+ Mid dermal elastolysis

+ Actinic degeneration of the corium

+ Pseudoxanthoma elasticum

+ Focal linear elastosis

+ Elastosis perforans serpiginosa

+ Vasculitides

+ Leukocytoclastic vasculitis

+ Other vasculitides

+ Polyarteritis nodosa

+ Eosinophilic vasculitis

+ Churg Strauss syndrome

+ Wegener's granulomatosis

+ Thrombangiitis obliterans (Bürger)

+ Livedo vasculitis

+ Disseminated intravascular coagulopathy (DIC)

+ Giant cell arteritis of Horton (temporal)

+ Purpura

+ Thrombotic thrombocytopenic purpura of Moschowitz

+ Urticarial vasculitis

+ Vasculitis and mycotic sepsis

+ Chronic venous insufficiency

+ Venous varices

+ Ulcus cruris

+ Superficial thrombosis

+ Superficial thrombophlebitis

+ Cutis marmorata, livedo reticularis, livedo racemosa

+ Cryoglobulinemia

+ Cryoglobulinemia in monoclonal gamapathy

+ Mixed cryoglobulinemia

+ Acrocyanosis

+ Malignant atrophic papulosis of Degos

+ Lymphedema

+ Lymphangitis

+ Acute lymphangitis

+ Sclerosing lymphangitis of the penis

+ Panniculitis

+ Erythema nodosum

+ Panniculitis arteficialis (factitial)

+ Calcifying panniculitis

+ Panniculitis caused by cold

+ Eosinophilic panniculitis

+ Lipomembranous panniculitis

+ Traumatic panniculitis

+ Panniculitis caused by steroids

+ Pancreatic panniculitis

+ Other panniculitides

+ Deposition of foreign material in the dermis

+ Amyloidosis

+ Systemic (secondary) amyloidosis

+ Mucinoses

+ Generalized myxedema in hypothyreosis

+ Pretibial myxedema

+ Reticular erythematous mucinosis

+ Papular mucinosis

+ Scleredema

+ Scleromyxedema

+ Myxoma

+ Digital myxoid cyst

+ Calcium deposits

+ Chronic dermatomyositis

+ Subepidermal calcifying nodule

+ Calcinosis scroti

+ Tumoriform calcinosis

+ Calciphylaxis

+ Dystrofic dermal calcifications

+ Osteoma cutis

+ Progressive osseous heteroplasia

+ Gout, arthritis uratica

+ Hemosiderin

+ Tatoo

+ Amalgam tatoo

+ Argyrosis

+ Titanium pigmentation

+ Deposits of corticosteroids in the dermis

+ Ochronosis

+ Colloid milium

+ Subcutaneous emphysema

+ Tumorous infiltration of the corium

+ Urticaria pigmentosa

+ Histiocytosis X

+ Metastatic infiltration of the dermis

+ Paget's carcinoma of the breast

+ Extramammary Paget's disease

+ Epidermal spread of colonic adenocarcinoma

+ Bacterial, mycotic and parazitic diseases; viruses

+ Bacterial inflammations with suppuration, pyodermia

+ Erosive pustulosis of the head

+ Erysipelas

+ Sepsis (bacterial)

+ Erysipeloid

+ Ecthyma

+ Orf

+ Angulus infectiosus

+ Aphta

+ Phlegmone, gangrene

+ Erythrasma

+ Pitted keratolysis

+ Borreliosis

+ Erythema chronicum migrans

+ Borreliosis (acrodermatitis chronica atrophicans)

+ Adnate listeriosis

+ Nail infection caused by Pseudomonas

+ Mycobacteria, actinomycetes

+ Tuberculosis cutis

+ Scrophuloderma

+ Lupus vulgaris

+ Reaction to BCG vaccination or sensitivity tests

+ Papulonecrotic tuberculid

+ Diseases caused by atypical mycobacteria

+ Leprosy

+ Actinomycosis

+ Madura foot

+ Rhinoscleroma

+ Francisella tularensis, tularemie

+ Mycotic diseases

+ Superficial tinea

+ Candidosis

+ Tinea nigra

+ Dermatophyton

+ Follicular mycosis

+ Deep mycotic processes

+ Cryptococcosis

+ Sporotrichosis

+ Onychomycosis

+ Paronychia candidomycetica

+ Diseases caused by parasites

+ Leishmaniasis

+ Demodicosis

+ Scabies

+ Larva migrans

+ Myiasis

+ Tungiasis

+ Pediculosis capitis

+ Pediculosis pubis

+ Pediculosis corporis

+ Cheyletielosis

+ Insect bite reaction

+ Tick

+ Trombicula autumnalis, Harvest mite

+ Injuries caused by animals

+ Bat bite reaction

+ Injury by stingray

+ Hand, foot and mouth disease

+ Gianotti Crosti syndrome

+ Diseases of hair follicles

+ Acne vulgaris

+ Rosacea

+ Dermatitis perioralis

+ Lupus miliaris disseminatus faciei

+ Alopecia

+ Alopecia areata

+ Diffuse alopecia

+ Defluvium

+ Pseudopelade of Brocq

+ Alopecia in lupus erythematodes

+ Follicular mucinosis (alopecia mucinosa)

+ Primary follicular mucinosis

+ Secondary follicular mucinosis in mycosis fungoides

+ Alopecia androgenica

+ Trichotillomania

+ Tration alopecia

+ Other diseases of hair follicles

+ Purulent folliculitis

+ Folliculitis keloidalis nuchae

+ Folliculitis decalvans, folliculitis abscedens et suffodiens, tufted hair folliculitis

+ Ostiofolliculitis (superficial folliculitis)

+ Perforating folliculitis

+ Eosinophilic pustular folliculitis, eosinophilic pustulosis

+ Eosinophilic pustulosis Ofuji

+ Keratosis pilaris

+ Lichen spinulosus

+ Trichostasis spinulosa

+ Ulerythema ophryogenes

+ Pili recurvati

+ Tufted hair

+ Plica polonica

+ Cutis verticis gyrata

+ Fox-Fordyce syndrome

+ Diseases of the nails

+ Posttraumatic onycholysis

+ Psoriatic onycholysis

+ Onychoschisis

+ Onychogryphosis

+ Onychophagia

+ Pterygium unguis

+ Unguis incarnatus

+ Foveolae unguis

+ Leuconychia striata

+ Melanonychia striata

+ Syndrome Laugier Hunziker

+ Twenty nail dystrophy

+ Disorders of the sweat glands

+ Hidradenitis axillaris (suppurativa)

+ Eccrine hidradenitis with neutrophils

+ Eccrine hidradenitis with neutrophils after chemotherapy

+ Miliaria

+ Necroses of eccrine sweat glands

+ Myoclonic epilepsy

+ Clear cell metaplasia of eccrine ducts

+ Syringomucinous metaplasia

+ Mucinous metaplasia

+ Sweat gland hyperplasia

+ Exogenic alterations of the skin

+ Scar

+ Cauterisatio

+ Combustio (burns)

+ Congelatio (frostbite)

+ Livedo e calore, erythema ab igne

+ Dermatitis artefacta

+ Arteficial dermatitis, caused by spray

+ Haematoma

+ Radiodermatitis

+ Radiodermatitis acute

+ Radiodermatitis, chronic

+ Phototoxic and photoallergic reactions

+ Berloque dermatitis

+ Syndrome Favre-Racouchot

+ Actinic damage of the skin

+ Metabolic and nutrition problems

+ Pellagra

+ Rachitis, avitaminosis D

+ Scorbut, avitaminosis C

+ Drug reactions

+ Lichenoid drug eruptions

+ Eczematoid drug reaction

+ Drug reaction, multiform type

+ Fixed drug reaction

+ Toxoallergic reaction

+ Vesicular drug reaction

+ Pustular drug reaction

+ Folliculitis caused by EGFR inhibitors therapy

+ Antagonists of TNF-α therapy

+ Therapy by tyrosinkinase inhibitors

+ Necrotising drug reaction

+ Other drug reactions

+ Coumarin necrosis, coumarin caused bleeding

+ Striae after prolonged therapy by corticosteroids

+ Organoid nevi and malformations of the skin

+ Nevus sebaceus (Jadassohn)

+ Epidermal nevus

+ Ichthyosis hystrix (widespread linear epidermal nevus)

+ Inflammatory linear verrucous epidermal nevus (ILVEN)

+ Nevus comedonicus

+ Familial dyskeratotic comedones

+ White sponge nevus of oral mucosa

+ Nevus lipomatosus

+ Nevus collagenicus

+ Fibrous hamartoma of infancy

+ Aplasia cutis congenita

+ Disorders of melanin pigmentation

+ Vitiligo

+ Hypomelanosis guttata

+ Pityriasis alba

+ Albinism

+ Melasma, chloasma

+ Ephelides, freckles

+ Melanocytic macule of the lip or genital

+ Dowling-Degos disease

+ Notalgia paresthetica

+ Melanodermatitis toxica, melanosis Riehl

+ Incontinentia pigmenti

+ Nevus achromicus

+ Other lesions

+ Fistula, sinus tract

+ Skin tumors

+ Diagnostic key to the most common epitelial skin tumors

+ Benign epidermal tumors

+ Seborrhoic keratosis

+ Melanoacanthoma

+ Dermatosis papulosa nigra

+ Lentigo solaris

+ Ink-spot lentigo

+ PUVA lentigo

+ Melanosis of Becker (Becker's nevus)

+ Stucco keratosis

+ Acrokeratosis verruciformis Hopf

+ Hyperkeratosis lenticularis perstans of Flegel

+ Confluent and reticulated papillomatosis

+ Acanthosis nigricans

+ Keratotic processes

+ Multiple minute digitate keratoses

+ Postirradiation hyperkeratoses

+ Minute aggregate keratoses

+ Waxy dermatosis

+ Warty dyskeratoma (solitary Darier's disease)

+ Acantholytic acanthoma

+ Verrucous affections caused by papillomavirus (HPV)

+ Verruca vulgaris

+ Verruca filiformis

+ Verruca plantaris

+ Verruca plana

+ Epidermodysplasia verruciformis

+ Condyloma acuminatum

+ Focal epithelial hyperplasia Heck, multifocal papillomavirus epithelial hyperplasia (MPVEH)

+ Hirsutes papillares

+ Bowenoid papulosis of the genitalia

+ Inverted follicular keratosis

+ Molluscum contagiosum

+ Arsenical keratosis

+ Large cell acanthoma

+ Epidermolytic acanthoma

+ Knuckle pads

+ Keratoacanthoma

+ Pale cell acanthoma

+ Pale cell papulosis

+ Pseudoepitheliomatous hyperplasia

+ Follicular induction

+ Sebaceous induction

+ Malignant epidermal tumors

+ Solar keratosis

+ Actinic cheilitis

+ Bowen's intraepidermal carcinoma

+ Bowen's disease, pagetoid

+ Queyrat's disease

+ Vulval intraepithelial neoplasia (VIN III.)

+ Dysplasia/in situ carcinoma from basaloid cells

+ Cornu cutaneum

+ Trichilemmal cornu cutaneum

+ Basalioma

+ Metatypic carcinoma (spinobasocellular)

+ Squamous cell carcinoma

+ Verrucous carcinoma

+ Giant condylomata of Buschke-Loewenstein

+ Basaloid, cloacogenic carcinoma

+ Lymphoepithelioma-like carcinoma of the skin

+ Adnexal tumors

+ Tumors of the hair follicle

+ Hair follicle nevus

+ Aberrant follicle

+ Trichofolliculoma

+ Trichoadenoma

+ Dilated pore of Winer

+ Pilar sheath acanthoma

+ Trichoepithelioma, superficial trichoblastoma

+ Trichoblastoma

+ Desmoplastic trichoepithelioma

+ Tricholemmoma

+ Desmoplastic tricholemmoma

+ Trichomatricoma (pilomatrixoma)

+ Trichomatrical carcinoma

+ Folliculosebaceous hamartoma

+ Tumor of the follicular infundibulum

+ Trichodiscoma

+ Perifollicular fibroma

+ Tumors of the sweat glands

+ Axillar heterotopia of mammary glands

+ Eccrine nevus

+ Apocrine nevus (hyperplasia)

+ Eccrine angiomatous hamartoma

+ Cylindroma

+ Spiradenoma

+ Nodular hidradenoma

+ Cystic nodular hidradenoma

+ Apocrine hidradenocarcinoma

+ Syringoma

+ Papillary eccrine adenoma

+ Apocrine nevus

+ Mammary gland anal polyp

+ Chondroid syringoma

+ Syringocystadenoma papilliferum

+ Hidradenoma papilliferum

+ Tubular apocrine adenoma

+ Adenoma of the nipple

+ Poroma

+ Eccrine poroma

+ Hidroacanthoma simplex

+ Dermal duct tumor

+ Poroma, malignant (porocarcinoma)

+ Syringofibroadenoma

+ Intraepidermal epithelioma of Borst Jadassohn

+ Microcystic adnexal carcinoma

+ Adenoid cystic carcinoma

+ Eccrine carcinoma

+ Mucinous carcinoma of the skin

+ Fibroadenoma

+ Sebaceous tumors

+ Ectopic sebaceous glands

+ Nevus sebaceus (of Jadassohn)

+ Sebaceous hyperplasia

+ Sebaceous hyperplasia of the penis

+ Sebaceous adenoma

+ Sebaceoma, sebaceous epithelioma

+ Muir-Torre syndrome

+ Combined adnexal tumor

+ Cowden syndrome

+ Mesenchymal tumors

+ Sclerosing fibroma

+ Dermatofibroma (histiocytoma of the skin)

+ Dermatomyofibroma

+ Atypical fibroxantoma

+ Dermatofibrosarcoma protuberans

+ Bednar tumor, pigmented dermatofibrosarcoma protuberans

+ Malignant fibrous histiocytoma, pleomorphic sarcoma

+ Giant cell fibroblastoma

+ Skin tags

+ Fibroepithelial polyp

+ Supernumerary digit

+ Supranumerary nipple

+ Accessory tragus

+ Fibrous papule of the nose (face)

+ Acral fibrokeratoma

+ Acquired periungal fibrokeratoma

+ Vestibular papules of the vulva

+ Focal dermal hypoplasia of Golz

+ Keloid

+ Lipoma

+ Common lipoma

+ Spindle cell and pleomorhic lipoma

+ Lipomatosis

+ Angiolipoma

+ Angiomyolipoma

+ Liposarcoma

+ Vascular tumors

+ Benign vascular tumors

+ Capillary hemangioma

+ Cavernous hemangioma

+ Sinusoidal hemangioma

+ Venous lake

+ Blue rubber bleb nevus syndrome

+ Naevus simplex

+ Nevus flammeus

+ Arteriovenous malformation

+ Venous malformation

+ Cutis marmorata teleangiectatica

+ Angioma serpiginosum

+ Ectatic superficial capillaries in areas of solar degeneration of elastic fibres

+ Congenital teleangiectatic erythema (Bloom's syndrome)

+ Osler Weber Rendu hereditary haemorrhagic telangiectasia

+ Spindle cell hemangioma

+ Angiokeratoma

+ Granulation tissue

+ Intravascular hemangioma of Masson

+ Granuloma pyogenicum

+ Senile hemangioma

+ Acquired tufted hemangioma

+ Microvenular hemangioma

+ Verrucous hemangioma

+ Targetoid hemosiderotic hemangioma

+ Nevus araneus

+ Acral arteriovenous hemangioma

+ Cherry hemangioma

+ Epithelioid hemangioma (angiolymphoid hyperplasia)

+ Kimura disease

+ Bacillary angiomatosis

+ Acroangiodermatitis

+ Nevus anemicus

+ Nodi hemorrhoidales

+ Vascular dilatation

+ Vascular tumors of borderline malignancy

+ Epithelioid hemangioendothelioma

+ Retiform hemangioendothelioma

+ Kaposiform hemangioendothelioma

+ Malignant tumors of blood vessels

+ Dabska tumor (papillary hemangioendothelioma)

+ Kaposi's sarcoma

+ Angiosarcoma

+ Tumors of lymphatic vessels

+ Lymphangioma

+ Glomus tumor

+ Glomangioma

+ Hemangiopericytoma

+ Tumors of the smooth muscle

+ Pilar leiomyomas

+ Angioleiomyoma

+ Genital leiomyomas

+ Leiomyosarcoma

+ Rhabdomyoma, rhabdomyomatous mesenchymal hamartoma

+ Adenoma (angiofibroma) sebaceum Pringle

+ Pearly penile papules

+ Histiocytic tumors and proliferations

+ Xanthoma

+ Juvenile xanthogranuloma

+ Necrobiotic xanthogranuloma

+ Reticulohistiocytoma

+ Benign cephalic histiocytosis

+ Giant cell tumor of the tendon sheath

+ Giant cell tumor of the skin or soft tissue

+ Histiocytic sarcoma

+ Neurogenic tumors

+ Benign neurogenic tumors

+ Neurofibroma

+ Recklinghausen's disease

+ Schwannoma (neurilemmoma)

+ Traumatic neuroma

+ Neurohamartoma

+ Neurothekeoma

+ Granular cell tumor, Abrikosoff

+ Malignant neurogenic tumors

+ Epithelioid sarcoma

+ Lymphomas

+ WHO classification of skin lymphomas

+ Pseudolymphoma, lymphocytoma

+ B cell pseudolymphoma

+ T cell pseudolymphoma

+ Cutaneous lymphoproliferative infiltrates other than lymphomas

+ Insect bite reaction

+ Sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman

+ Leishmaniasis

+ Angioimmunoblastic lymphadenopathy

+ Skin lesions in nodal lymphomas

+ T cell lymphomas

+ Small plaque parapsoriasis

+ Large plaque parapsoriasis

+ Mycosis fungoides

+ Folliculotropic mycosis fungoides

+ Granulomatous Slack Skin

+ Pagetoid reticulosis Worringer Kolopp

+ Sézary syndrome

+ CD 30+ T cell lymphoproliferative disorders of the skin

+ Lymphomatoid papulosis

+ Anaplastic large cell lymphoma T

+ Subcutaneous panniculitis-like alpha/beta T cell lymphoma

+ Primary cutaneous peripheral T cell lymphoma, unspecified

+ CD8 positive T cell lymphoma (cytotoxic)

+ T cell receptor gamma/delta chain positive cutaneous lymphoma

+ Pleomorphic small to medium-sized T cell lymphoma

+ NK cell lymphoma (CD56+)

+ Adult T cell lymphoma

+ Syringolymphoid hyperplasia with alopecia

+ Pleomorphic medium-sized and large T cell lymphoma (HTLV-1 +/-)

+ Juvenile granulomatous cutaneous T cell lymphoma

+ B cell rich T cell lymphoma

+ Angiocentric and angiodestructive lymphoma

+ T zone lymphoma, Lennert and Mohri

+ Intravascular T lymphoma

+ B cell lymphomas

+ Follicular lymphoma

+ Secondary skin infiltration in nodal follicular lymphoma

+ Marginal zone lymphoma

+ Marginal zone lymphoma, immunocytoma variant

+ Marginal zone lymphoma, plasmocytoma variant

+ Large cell diffuse B cutaneous lymphoma

+ Large B cell diffuse lymphoma, leg type

+ Large cell diffuse B lymphoma, other than leg type

+ T cell rich B cell lymphoma

+ Intravascular B lymphoma

+ Lymphoblastic lymphoma B

+ Lymphomatoid granulomatosis (Liebow)

+ Lymphatic leukemia B

+ Mantle cell lymphoma

+ Burkitt lymphoma

+ Acute hematopoietic malignancies

+ Blastic NK cell lymphoma CD4+/CD56+ hematodermic neoplasm

+ Precursor lymphoblastic leukemia/lymphoma

+ Precursor lymphoblastic leukemia/lymphoma B

+ Precursor lymphoblastic leukemia/lymphoma T

+ Hodgkin's disease of the skin

+ Skin infiltrates in granulocytic malignancies

+ Acute myeloic leukemia

+ Myelosarcoma

+ Chloroma

+ Melanocytic tumors

+ Melanocytic nevus

+ Common melanocytic nevi

+ Lentigo simplex

+ Junctional melanocytic nevus

+ Compound melanocytic nevus

+ Dermal nevus

+ Speckled lentiginous nevus, nevus spilus

+ Balloon cell nevus

+ Halo nevus

+ Melanocytic nevus with clonal proliferation

+ Eczematized melanocytic nevus

+ Recurrent melanocytic nevus

+ Melanocytic nevus on a skin graft

+ Melanocytic nevus in pregnancy

+ Giant melanocytic nevus

+ Deep penetrating nevus

+ Nevus Spitz

+ BAP-1 negative melanocytic nevus

+ Pigmented spindle cell nevus (Reed)

+ Blue nevus

+ Blue nevus of common type, of dendritic melanocytes

+ Cellular blue nevus

+ Special forms of blue nevi

+ Combined nevi

+ Melanocytic nevus of the conjunctiva

+ Melanoma

+ Lentigo maligna

+ Lentigo maligna melanoma

+ Intraepidermal melanoma (melanoma in situ)

+ Superficial spreading melanoma, SSM

+ Superficial spreading melanoma, vertical growth

+ Nodular melanoma

+ Nevoid melanoma

+ Acrolentiginous and mucosal melanoma

+ Melanoma ex nevo

+ Balloon cell melanoma

+ Small cell melanoma

+ Desmoplastic melanoma

+ Melanoma developing within congenital nevus, child, 6 years

+ Melanoma of the conjunctiva

+ Melanoma metastases

+ Merkel cell carcinoma

+ Cysts of the skin and subcutis

+ Cysts with epithelial lining

+ Cysts with lining of epidermal type

+ Epidermal (infundibular) cyst

+ Epidermal cyst combined with HPV infection

+ Epidermal verrucous cyst combined with HPV infection

+ Epidermal inclusion cyst

+ Hair matrix cyst

+ Epidermal proliferating cyst

+ Trichilemmal cyst

+ Proliferating trichilemmal cyst

+ Dermoid cyst

+ Cystic teratoma

+ Cystic teratoma of the ovary

+ Pigmented follicular cyst

+ Steatocystoma multiplex

+ Skin keratocyst

+ Vellus hair cyst

+ Cystis colli mediana, thyreoglossal duct cyst

+ Giant comedo

+ Milium

+ Preauricular sinus (pit)

+ Thymic cyst

+ Bronchogenic cyst

+ Branchial cleft cyst

+ Cutaneous ciliated cyst of the lower limbs

+ Vulval mucinous and ciliated cyst

+ Gartner's duct cyst

+ Endometriosis

+ Median raphe cyst

+ Hidrocystoma

+ Eccrine hidrocystoma

+ Apocrinne hidrocystoma (and its papillary variant)

+ Apocrine cystadenoma (papillary)

+ Non-epithelial cysts, pseudocysts

+ Ganglion, synovial cyst

+ Digital mucous cyst

+ Mucocele

+ Pilonidal sinus

+ Pseudocyst of the auricle

+ Parasitic cyst

+ Soft tissue lesions

+ Some lesions of the oral cavity

+ Dermatovenerology

+ Syphilis

+ Gonorrhea

+ Trichomonas vaginalis

+ Pathology of the foreskin, phimosis, balanitis

+ Balanitis

+ Balanitis plasmocellularis Zoon

+ Balanitis circinata

+ Phimosis, paraphimosis, frenulum breve and other lesions of the penis

+ Collection of histological slides by prof. Günter Burg

+ Collection of histological slides by prof. Werner Kempf

+ Collection of histological slides of dr. Ram Chandra Adhikari

T zone lymphoma, Lennert and Mohri

Introduction

Lymphoproliferative disorder, considered to be the T-cell lymphoma equivalent of follicular B cell lymphoma.

Clinical signs

lymphadenopathy, later hepatomegaly and/or splenomegaly and in 40% of cases lung involvement
unspecific skin reactions (rash, pruritus) in 30%
erythematous plaques or deep nodular livid lesions on the face or trunk
prognosis is bad (extracutaneous spread)

Histology

Diffuse, non epidermotropic infiltration of atypical small to medium-sized pleomorphic T lymphocytes in the expanded interfollicular areas (T-zones), affecting the entire dermis and subcutis.

Hallmark: remnants of follicular structures.

Small foci of chromatin-dense well differentiated small B lymphocytes, some immunoblasts and histiocytes and proliferation of postcapillary venules with high endothelial cells.

Immunophenotype and genetic features:

CD3+, CD4+, CD43+, CD45RO
CD8-, CD45RA-, CD20-, CD30-
S100 protein shows a dense network of interdigitating reticulum cells typical for the T-zone of the lymphnode
clonal rearangement of TCR beta genes in a majority of cases while the immunoglobulin genes remain in germinal configuration