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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Using this atlas
+ Conditions of using this atlas
+ Technical notes
+ Hardware
+ Software
+ How to use the atlas
+ Navigating through the text pages
+ Controlling the pictures
+ Logos and labels
+ What will you need to use the atlas
+ Bugs, problems
+ Netscape
+ Microsoft Internet Explorer
+ Some other Internet resources concerning dermatopathology and pathology
+ Literature
+ The literature used to prepare this atlas
+ Publications concerning the atlas
+ Support
+ Support
+ Skin biopsy
+ Examples of special stainings
+ Polarization
+ Immunofluorescence
+ Direct Immunofluorescence
+ Pemphigus vulgaris and its variants (immunofluorescence)
+ Bullous pemphigoid (immunofluorescence)
+ Pemphigoid (herpes) gestationis (immunofluorescence)
+ Dermatitis herpetiformis Duhring (immunofluorescence)
+ Lupus erythematosus (SLE, CDE a SCLE); (immunofluorescence)
+ Sharp's syndrome
+ Lichen ruber planus (immunofluorescence)
+ Vasculitis, immunocomplex type (immunofluorescence)
+ Porphyria cutanea tarda (PCT) and hepatopathies (immunofluorescence)
+ Indirect immunofluorescence
+ Antinuclear antibodies (ANA)
+ Endomysial antibodies
+ Antibodies aganist neutrophilic cytoplasm (ANCA)
+ Non-tumorous skin diseases
+ Diseases of the Epidermis
+ Ichthyosis
+ Ichthyosis vulgaris
+ Ichthyosis lamellaris
+ X-linked ichthyosis
+ Epidermolytic hyperkeratosis
+ Ichthyosis acquisita
+ Keratosis palmoplantaris, palmoplantar keratoderma
+ Ectodermal dysplasia
+ Psoriasis
+ Psoriatic erytroderma
+ Palmoplantar psoriasis and palmoplantar pustulosis
+ Generalized pustular psoriasis of Zumbusch
+ Lingua geographica
+ Psoriatiform keratosis
+ Infantile acropustulosis
+ Darier's disease
+ Porokeratosis
+ Acrokeratoelastoidosis
+ Pityriasis rubra pilaris
+ Glucagonoma syndrome
+ Acrodermatitis enteropathica
+ Blistering diseases
+ Classification
+ Impetigo
+ Staphylococcal scalded skin syndrome
+ Subcorneal pustular dermatosis of Sneddon-Wilkinson
+ Peeling skin syndrome
+ Acute generalized exanthematous pustulosis (AGEP)
+ Pemphigus vulgaris
+ Pemphigus vegetans
+ Neonatal pemphigus
+ Pemphigus erythematosus Senear-Usher
+ Pemphigus foliaceus
+ Paraneoplastic pemphigus
+ IgA pemphigus
+ Hailey-Hailey (Familial benign pemphigus)
+ Transient acantholytic dermatosis (of Grover)
+ Herpes zoster, varicella, Herpes simplex
+ Herpes simplex
+ Eczema herpeticatum Kaposi Juliusberg
+ Herpes zoster, varicella
+ Bullous pemphigoid
+ Cicatricial pemphigoid
+ Pemphigoid (herpes) gestationis
+ Porphyria cutanea tarda
+ Pseudoporphyria
+ Bulla in diabetes
+ Dermatitis herpetiformis Duhring
+ IgA linear dermatosis
+ Erythema multiforme
+ Toxic epidermal necrolysis of Lyell
+ Stevens-Johnson syndrome
+ Graft versus host reaction
+ Epidermolysis bullosa
+ Epidermolysis bullosa dystrophica
+ Epidermolysis bullosa acquisita
+ Artifical clefts in basaliomas
+ Allergic contact dermatitis, acute
+ Dyshidrotic dermatitis
+ Eczema atopicum (dermatitis atopica)
+ Subacute and chronic (eczem) dermatitis
+ Microbial eczema
+ Granuloma gluteale infantum
+ Toxic contact (irritative) dermatitis, acute
+ Toxic contact (irritative) dermatitis, chronic
+ Seborrhoic dermatitis
+ Pityriasis amiantacea
+ Changes caused by rubbing, scratching and pressure
+ Lichen simplex
+ Strophulus
+ Prurigo gestationis
+ Prurigo nodularis
+ Prurigo senilis
+ Atopic dermatitis
+ Picker's nodule
+ Excoriation
+ Chronic pressure (hip)
+ Amputation stump
+ Granuloma fissuratum
+ Pressure necrosis
+ Tyloma, callus
+ Clavus
+ Morsicatio buccarum
+ Perivascular infiltration of upper dermis
+ Pityriasis lichenoides Mucha Habermann
+ Pityriasis lichenoides acuta
+ Pityriasis lichenoides chronica
+ Pityriasis rosea Gibert
+ Diffuse infiltration infiltration of the upper dermis
+ Lichen ruber planus
+ Lichen verrucosus (hypertrophicus)
+ Lichen ruber, vesicular
+ Lichen planopilaris
+ Lichen planus like keratosis (benign lichenoid keratosis)
+ Lichenoid drug reaction
+ Lichen nitidus
+ Lichen striatus
+ Erythema dyschromicum perstans
+ Poikiloderma Rothmund Thomson
+ Poikiloderma vasculare atrophicans
+ Infiltration of the upper and deep corium
+ Erythema annulare centrifugum (erythema figuratum)
+ Erythema gyratum repens
+ Lymphocytic infiltrate of Jessner-Kanof
+ Urticaria
+ Pruritic urticarial papules and plaques of pregnancy (PUPPP)
+ Well's syndrome
+ Hypereosinophilic syndrome
+ Granuloma faciale (eosinophilicum)
+ Erythema elevatum diutinum
+ Sweet's syndrome
+ Behcet's disease
+ Pyoderma gangrenosum
+ Granulomatous processes of deeper corium
+ Granuloma annulare
+ Granuloma annulare, deep
+ Granuloma multiforme
+ Annular elastolytic granuloma
+ Necrobiosis lipoidica
+ Granulomatosis disciformis Miescher
+ Rheumatoid nodule
+ Chondrodermatitis nodularis chronica helicis
+ Polychondritis recurrens
+ Sarcoidosis
+ Erythema induratum Bazin
+ Foreign body granulomas
+ Silicone granuloma
+ Cat scratch disease
+ Cheilitis granulomatosa Miescher Melkerson Rosenthal
+ Intersticial granulomatous dermatitis
+ Crohn's disease, skin changes
+ Connective tissue disorders
+ Lupus erythematosus
+ Lupus erythematodes, acute
+ Acute neonatal lupus erythematodes
+ Lupus erythematodes, subacute
+ Lupus erythematodes, chronic
+ Lupus erythematodes profundus
+ Dermatomyositis
+ Osteoarthritis, Heberden nodes
+ Scleroderma, morphea
+ Diffuse scleroderma
+ Localized scleroderma, morphea
+ Lichen sclerosus et atrophicus
+ Pachydermoperiostosis
+ Eosinophilic fasciitis
+ Fibromatosis
+ Infantile digital fibromatosis (inclusion body fibromatosis)
+ Intravascular fasciitis
+ Desmoid type fibromatosis, desmoid
+ Striae distensae
+ Skin graft
+ Perforating collagenosis
+ Disorders of elastic fibres
+ Anetoderma
+ Mid dermal elastolysis
+ Actinic degeneration of the corium
+ Pseudoxanthoma elasticum
+ Focal linear elastosis
+ Elastosis perforans serpiginosa
+ Vasculitides
+ Leukocytoclastic vasculitis
+ Other vasculitides
+ Polyarteritis nodosa
+ Eosinophilic vasculitis
+ Churg Strauss syndrome
+ Wegener's granulomatosis
+ Thrombangiitis obliterans (Bürger)
+ Livedo vasculitis
+ Disseminated intravascular coagulopathy (DIC)
+ Giant cell arteritis of Horton (temporal)
+ Purpura
+ Thrombotic thrombocytopenic purpura of Moschowitz
+ Urticarial vasculitis
+ Vasculitis and mycotic sepsis
+ Chronic venous insufficiency
+ Venous varices
+ Ulcus cruris
+ Superficial thrombosis
+ Superficial thrombophlebitis
+ Cutis marmorata, livedo reticularis, livedo racemosa
+ Cryoglobulinemia
+ Cryoglobulinemia in monoclonal gamapathy
+ Mixed cryoglobulinemia
+ Acrocyanosis
+ Malignant atrophic papulosis of Degos
+ Lymphedema
+ Lymphangitis
+ Acute lymphangitis
+ Sclerosing lymphangitis of the penis
+ Panniculitis
+ Erythema nodosum
+ Panniculitis arteficialis (factitial)
+ Calcifying panniculitis
+ Panniculitis caused by cold
+ Eosinophilic panniculitis
+ Lipomembranous panniculitis
+ Traumatic panniculitis
+ Panniculitis caused by steroids
+ Pancreatic panniculitis
+ Other panniculitides
+ Deposition of foreign material in the dermis
+ Amyloidosis
+ Systemic (secondary) amyloidosis
+ Mucinoses
+ Generalized myxedema in hypothyreosis
+ Pretibial myxedema
+ Reticular erythematous mucinosis
+ Papular mucinosis
+ Scleredema
+ Scleromyxedema
+ Myxoma
+ Digital myxoid cyst
+ Calcium deposits
+ Chronic dermatomyositis
+ Subepidermal calcifying nodule
+ Calcinosis scroti
+ Tumoriform calcinosis
+ Calciphylaxis
+ Dystrofic dermal calcifications
+ Osteoma cutis
+ Progressive osseous heteroplasia
+ Gout, arthritis uratica
+ Hemosiderin
+ Tatoo
+ Amalgam tatoo
+ Argyrosis
+ Titanium pigmentation
+ Deposits of corticosteroids in the dermis
+ Ochronosis
+ Colloid milium
+ Subcutaneous emphysema
+ Tumorous infiltration of the corium
+ Urticaria pigmentosa
+ Histiocytosis X
+ Metastatic infiltration of the dermis
+ Paget's carcinoma of the breast
+ Extramammary Paget's disease
+ Epidermal spread of colonic adenocarcinoma
+ Bacterial, mycotic and parazitic diseases; viruses
+ Bacterial inflammations with suppuration, pyodermia
+ Erosive pustulosis of the head
+ Erysipelas
+ Sepsis (bacterial)
+ Erysipeloid
+ Ecthyma
+ Orf
+ Angulus infectiosus
+ Aphta
+ Phlegmone, gangrene
+ Erythrasma
+ Pitted keratolysis
+ Borreliosis
+ Erythema chronicum migrans
+ Borreliosis (acrodermatitis chronica atrophicans)
+ Adnate listeriosis
+ Nail infection caused by Pseudomonas
+ Mycobacteria, actinomycetes
+ Tuberculosis cutis
+ Scrophuloderma
+ Lupus vulgaris
+ Reaction to BCG vaccination or sensitivity tests
+ Papulonecrotic tuberculid
+ Diseases caused by atypical mycobacteria
+ Leprosy
+ Actinomycosis
+ Madura foot
+ Rhinoscleroma
+ Francisella tularensis, tularemie
+ Mycotic diseases
+ Superficial tinea
+ Candidosis
+ Tinea nigra
+ Dermatophyton
+ Follicular mycosis
+ Deep mycotic processes
+ Cryptococcosis
+ Sporotrichosis
+ Onychomycosis
+ Paronychia candidomycetica
+ Diseases caused by parasites
+ Leishmaniasis
+ Demodicosis
+ Scabies
+ Larva migrans
+ Myiasis
+ Tungiasis
+ Pediculosis capitis
+ Pediculosis pubis
+ Pediculosis corporis
+ Cheyletielosis
+ Insect bite reaction
+ Tick
+ Trombicula autumnalis, Harvest mite
+ Injuries caused by animals
+ Bat bite reaction
+ Injury by stingray
+ Hand, foot and mouth disease
+ Gianotti Crosti syndrome
+ Diseases of hair follicles
+ Acne vulgaris
+ Rosacea
+ Dermatitis perioralis
+ Lupus miliaris disseminatus faciei
+ Alopecia
+ Alopecia areata
+ Diffuse alopecia
+ Defluvium
+ Pseudopelade of Brocq
+ Alopecia in lupus erythematodes
+ Follicular mucinosis (alopecia mucinosa)
+ Primary follicular mucinosis
+ Secondary follicular mucinosis in mycosis fungoides
+ Alopecia androgenica
+ Trichotillomania
+ Tration alopecia
+ Other diseases of hair follicles
+ Purulent folliculitis
+ Folliculitis keloidalis nuchae
+ Folliculitis decalvans, folliculitis abscedens et suffodiens, tufted hair folliculitis
+ Ostiofolliculitis (superficial folliculitis)
+ Perforating folliculitis
+ Eosinophilic pustular folliculitis, eosinophilic pustulosis
+ Eosinophilic pustulosis Ofuji
+ Keratosis pilaris
+ Lichen spinulosus
+ Trichostasis spinulosa
+ Ulerythema ophryogenes
+ Pili recurvati
+ Tufted hair
+ Plica polonica
+ Cutis verticis gyrata
+ Fox-Fordyce syndrome
+ Diseases of the nails
+ Posttraumatic onycholysis
+ Psoriatic onycholysis
+ Onychoschisis
+ Onychogryphosis
+ Onychophagia
+ Pterygium unguis
+ Unguis incarnatus
+ Foveolae unguis
+ Leuconychia striata
+ Melanonychia striata
+ Syndrome Laugier Hunziker
+ Twenty nail dystrophy
+ Disorders of the sweat glands
+ Hidradenitis axillaris (suppurativa)
+ Eccrine hidradenitis with neutrophils
+ Eccrine hidradenitis with neutrophils after chemotherapy
+ Miliaria
+ Necroses of eccrine sweat glands
+ Myoclonic epilepsy
+ Clear cell metaplasia of eccrine ducts
+ Syringomucinous metaplasia
+ Mucinous metaplasia
+ Sweat gland hyperplasia
+ Exogenic alterations of the skin
+ Scar
+ Cauterisatio
+ Combustio (burns)
+ Congelatio (frostbite)
+ Livedo e calore, erythema ab igne
+ Dermatitis artefacta
+ Arteficial dermatitis, caused by spray
+ Haematoma
+ Radiodermatitis
+ Radiodermatitis acute
+ Radiodermatitis, chronic
+ Phototoxic and photoallergic reactions
+ Berloque dermatitis
+ Syndrome Favre-Racouchot
+ Actinic damage of the skin
+ Metabolic and nutrition problems
+ Pellagra
+ Rachitis, avitaminosis D
+ Scorbut, avitaminosis C
+ Drug reactions
+ Lichenoid drug eruptions
+ Eczematoid drug reaction
+ Drug reaction, multiform type
+ Fixed drug reaction
+ Toxoallergic reaction
+ Vesicular drug reaction
+ Pustular drug reaction
+ Folliculitis caused by EGFR inhibitors therapy
+ Antagonists of TNF-α therapy
+ Therapy by tyrosinkinase inhibitors
+ Necrotising drug reaction
+ Other drug reactions
+ Coumarin necrosis, coumarin caused bleeding
+ Striae after prolonged therapy by corticosteroids
+ Organoid nevi and malformations of the skin
+ Nevus sebaceus (Jadassohn)
+ Epidermal nevus
+ Ichthyosis hystrix (widespread linear epidermal nevus)
+ Inflammatory linear verrucous epidermal nevus (ILVEN)
+ Nevus comedonicus
+ Familial dyskeratotic comedones
+ White sponge nevus of oral mucosa
+ Nevus lipomatosus
+ Nevus collagenicus
+ Fibrous hamartoma of infancy
+ Aplasia cutis congenita
+ Disorders of melanin pigmentation
+ Vitiligo
+ Hypomelanosis guttata
+ Pityriasis alba
+ Albinism
+ Melasma, chloasma
+ Ephelides, freckles
+ Melanocytic macule of the lip or genital
+ Dowling-Degos disease
+ Notalgia paresthetica
+ Melanodermatitis toxica, melanosis Riehl
+ Incontinentia pigmenti
+ Nevus achromicus
+ Other lesions
+ Fistula, sinus tract
+ Skin tumors
+ Diagnostic key to the most common epitelial skin tumors
+ Benign epidermal tumors
+ Seborrhoic keratosis
+ Melanoacanthoma
+ Dermatosis papulosa nigra
+ Lentigo solaris
+ Ink-spot lentigo
+ PUVA lentigo
+ Melanosis of Becker (Becker's nevus)
+ Stucco keratosis
+ Acrokeratosis verruciformis Hopf
+ Hyperkeratosis lenticularis perstans of Flegel
+ Confluent and reticulated papillomatosis
+ Acanthosis nigricans
+ Keratotic processes
+ Multiple minute digitate keratoses
+ Postirradiation hyperkeratoses
+ Minute aggregate keratoses
+ Waxy dermatosis
+ Warty dyskeratoma (solitary Darier's disease)
+ Acantholytic acanthoma
+ Verrucous affections caused by papillomavirus (HPV)
+ Verruca vulgaris
+ Verruca filiformis
+ Verruca plantaris
+ Verruca plana
+ Epidermodysplasia verruciformis
+ Condyloma acuminatum
+ Focal epithelial hyperplasia Heck, multifocal papillomavirus epithelial hyperplasia (MPVEH)
+ Hirsutes papillares
+ Bowenoid papulosis of the genitalia
+ Inverted follicular keratosis
+ Molluscum contagiosum
+ Arsenical keratosis
+ Large cell acanthoma
+ Epidermolytic acanthoma
+ Knuckle pads
+ Keratoacanthoma
+ Pale cell acanthoma
+ Pale cell papulosis
+ Pseudoepitheliomatous hyperplasia
+ Follicular induction
+ Sebaceous induction
+ Malignant epidermal tumors
+ Solar keratosis
+ Actinic cheilitis
+ Bowen's intraepidermal carcinoma
+ Bowen's disease, pagetoid
+ Queyrat's disease
+ Vulval intraepithelial neoplasia (VIN III.)
+ Dysplasia/in situ carcinoma from basaloid cells
+ Cornu cutaneum
+ Trichilemmal cornu cutaneum
+ Basalioma
+ Metatypic carcinoma (spinobasocellular)
+ Squamous cell carcinoma
+ Verrucous carcinoma
+ Giant condylomata of Buschke-Loewenstein
+ Basaloid, cloacogenic carcinoma
+ Lymphoepithelioma-like carcinoma of the skin
+ Adnexal tumors
+ Tumors of the hair follicle
+ Hair follicle nevus
+ Aberrant follicle
+ Trichofolliculoma
+ Trichoadenoma
+ Dilated pore of Winer
+ Pilar sheath acanthoma
+ Trichoepithelioma, superficial trichoblastoma
+ Trichoblastoma
+ Desmoplastic trichoepithelioma
+ Tricholemmoma
+ Desmoplastic tricholemmoma
+ Trichomatricoma (pilomatrixoma)
+ Trichomatrical carcinoma
+ Folliculosebaceous hamartoma
+ Tumor of the follicular infundibulum
+ Trichodiscoma
+ Perifollicular fibroma
+ Tumors of the sweat glands
+ Axillar heterotopia of mammary glands
+ Eccrine nevus
+ Apocrine nevus (hyperplasia)
+ Eccrine angiomatous hamartoma
+ Cylindroma
+ Spiradenoma
+ Nodular hidradenoma
+ Cystic nodular hidradenoma
+ Apocrine hidradenocarcinoma
+ Syringoma
+ Papillary eccrine adenoma
+ Apocrine nevus
+ Mammary gland anal polyp
+ Chondroid syringoma
+ Syringocystadenoma papilliferum
+ Hidradenoma papilliferum
+ Tubular apocrine adenoma
+ Adenoma of the nipple
+ Poroma
+ Eccrine poroma
+ Hidroacanthoma simplex
+ Dermal duct tumor
+ Poroma, malignant (porocarcinoma)
+ Syringofibroadenoma
+ Intraepidermal epithelioma of Borst Jadassohn
+ Microcystic adnexal carcinoma
+ Adenoid cystic carcinoma
+ Eccrine carcinoma
+ Mucinous carcinoma of the skin
+ Fibroadenoma
+ Sebaceous tumors
+ Ectopic sebaceous glands
+ Nevus sebaceus (of Jadassohn)
+ Sebaceous hyperplasia
+ Sebaceous hyperplasia of the penis
+ Sebaceous adenoma
+ Sebaceoma, sebaceous epithelioma
+ Muir-Torre syndrome
+ Combined adnexal tumor
+ Cowden syndrome
+ Mesenchymal tumors
+ Sclerosing fibroma
+ Dermatofibroma (histiocytoma of the skin)
+ Dermatomyofibroma
+ Atypical fibroxantoma
+ Dermatofibrosarcoma protuberans
+ Bednar tumor, pigmented dermatofibrosarcoma protuberans
+ Malignant fibrous histiocytoma, pleomorphic sarcoma
+ Giant cell fibroblastoma
+ Skin tags
+ Fibroepithelial polyp
+ Supernumerary digit
+ Supranumerary nipple
+ Accessory tragus
+ Fibrous papule of the nose (face)
+ Acral fibrokeratoma
+ Acquired periungal fibrokeratoma
+ Vestibular papules of the vulva
+ Focal dermal hypoplasia of Golz
+ Keloid
+ Lipoma
+ Common lipoma
+ Spindle cell and pleomorhic lipoma
+ Lipomatosis
+ Angiolipoma
+ Angiomyolipoma
+ Liposarcoma
+ Vascular tumors
+ Benign vascular tumors
+ Capillary hemangioma
+ Cavernous hemangioma
+ Sinusoidal hemangioma
+ Venous lake
+ Blue rubber bleb nevus syndrome
+ Naevus simplex
+ Nevus flammeus
+ Arteriovenous malformation
+ Venous malformation
+ Cutis marmorata teleangiectatica
+ Angioma serpiginosum
+ Ectatic superficial capillaries in areas of solar degeneration of elastic fibres
+ Congenital teleangiectatic erythema (Bloom's syndrome)
+ Osler Weber Rendu hereditary haemorrhagic telangiectasia
+ Spindle cell hemangioma
+ Angiokeratoma
+ Granulation tissue
+ Intravascular hemangioma of Masson
+ Granuloma pyogenicum
+ Senile hemangioma
+ Acquired tufted hemangioma
+ Microvenular hemangioma
+ Verrucous hemangioma
+ Targetoid hemosiderotic hemangioma
+ Nevus araneus
+ Acral arteriovenous hemangioma
+ Cherry hemangioma
+ Epithelioid hemangioma (angiolymphoid hyperplasia)
+ Kimura disease
+ Bacillary angiomatosis
+ Acroangiodermatitis
+ Nevus anemicus
+ Nodi hemorrhoidales
+ Vascular dilatation
+ Vascular tumors of borderline malignancy
+ Epithelioid hemangioendothelioma
+ Retiform hemangioendothelioma
+ Kaposiform hemangioendothelioma
+ Malignant tumors of blood vessels
+ Dabska tumor (papillary hemangioendothelioma)
+ Kaposi's sarcoma
+ Angiosarcoma
+ Tumors of lymphatic vessels
+ Lymphangioma
+ Glomus tumor
+ Glomangioma
+ Hemangiopericytoma
+ Tumors of the smooth muscle
+ Pilar leiomyomas
+ Angioleiomyoma
+ Genital leiomyomas
+ Leiomyosarcoma
+ Rhabdomyoma, rhabdomyomatous mesenchymal hamartoma
+ Adenoma (angiofibroma) sebaceum Pringle
+ Pearly penile papules
+ Histiocytic tumors and proliferations
+ Xanthoma
+ Juvenile xanthogranuloma
+ Necrobiotic xanthogranuloma
+ Reticulohistiocytoma
+ Benign cephalic histiocytosis
+ Giant cell tumor of the tendon sheath
+ Giant cell tumor of the skin or soft tissue
+ Histiocytic sarcoma
+ Neurogenic tumors
+ Benign neurogenic tumors
+ Neurofibroma
+ Recklinghausen's disease
+ Schwannoma (neurilemmoma)
+ Traumatic neuroma
+ Neurohamartoma
+ Neurothekeoma
+ Granular cell tumor, Abrikosoff
+ Malignant neurogenic tumors
+ Epithelioid sarcoma
+ Lymphomas
+ WHO classification of skin lymphomas
+ Pseudolymphoma, lymphocytoma
+ B cell pseudolymphoma
+ T cell pseudolymphoma
+ Cutaneous lymphoproliferative infiltrates other than lymphomas
+ Insect bite reaction
+ Sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman
+ Leishmaniasis
+ Angioimmunoblastic lymphadenopathy
+ Skin lesions in nodal lymphomas
+ T cell lymphomas
+ Small plaque parapsoriasis
+ Large plaque parapsoriasis
+ Mycosis fungoides
+ Folliculotropic mycosis fungoides
+ Granulomatous Slack Skin
+ Pagetoid reticulosis Worringer Kolopp
+ Sézary syndrome
+ CD 30+ T cell lymphoproliferative disorders of the skin
+ Lymphomatoid papulosis
+ Anaplastic large cell lymphoma T
+ Subcutaneous panniculitis-like alpha/beta T cell lymphoma
+ Primary cutaneous peripheral T cell lymphoma, unspecified
+ CD8 positive T cell lymphoma (cytotoxic)
+ T cell receptor gamma/delta chain positive cutaneous lymphoma
+ Pleomorphic small to medium-sized T cell lymphoma
+ NK cell lymphoma (CD56+)
+ Adult T cell lymphoma
+ Syringolymphoid hyperplasia with alopecia
+ Pleomorphic medium-sized and large T cell lymphoma (HTLV-1 +/-)
+ Juvenile granulomatous cutaneous T cell lymphoma
+ B cell rich T cell lymphoma
+ Angiocentric and angiodestructive lymphoma
+ T zone lymphoma, Lennert and Mohri
+ Intravascular T lymphoma
+ B cell lymphomas
+ Follicular lymphoma
+ Secondary skin infiltration in nodal follicular lymphoma
+ Marginal zone lymphoma
+ Marginal zone lymphoma, immunocytoma variant
+ Marginal zone lymphoma, plasmocytoma variant
+ Large cell diffuse B cutaneous lymphoma
+ Large B cell diffuse lymphoma, leg type
+ Large cell diffuse B lymphoma, other than leg type
+ T cell rich B cell lymphoma
+ Intravascular B lymphoma
+ Lymphoblastic lymphoma B
+ Lymphomatoid granulomatosis (Liebow)
+ Lymphatic leukemia B
+ Mantle cell lymphoma
+ Burkitt lymphoma
+ Acute hematopoietic malignancies
+ Blastic NK cell lymphoma CD4+/CD56+ hematodermic neoplasm
+ Precursor lymphoblastic leukemia/lymphoma
+ Precursor lymphoblastic leukemia/lymphoma B
+ Precursor lymphoblastic leukemia/lymphoma T
+ Hodgkin's disease of the skin
+ Skin infiltrates in granulocytic malignancies
+ Acute myeloic leukemia
+ Myelosarcoma
+ Chloroma
+ Melanocytic tumors
+ Melanocytic nevus
+ Common melanocytic nevi
+ Lentigo simplex
+ Junctional melanocytic nevus
+ Compound melanocytic nevus
+ Dermal nevus
+ Speckled lentiginous nevus, nevus spilus
+ Balloon cell nevus
+ Halo nevus
+ Melanocytic nevus with clonal proliferation
+ Eczematized melanocytic nevus
+ Recurrent melanocytic nevus
+ Melanocytic nevus on a skin graft
+ Melanocytic nevus in pregnancy
+ Giant melanocytic nevus
+ Deep penetrating nevus
+ Nevus Spitz
+ BAP-1 negative melanocytic nevus
+ Pigmented spindle cell nevus (Reed)
+ Blue nevus
+ Blue nevus of common type, of dendritic melanocytes
+ Cellular blue nevus
+ Special forms of blue nevi
+ Combined nevi
+ Melanocytic nevus of the conjunctiva
+ Melanoma
+ Lentigo maligna
+ Lentigo maligna melanoma
+ Intraepidermal melanoma (melanoma in situ)
+ Superficial spreading melanoma, SSM
+ Superficial spreading melanoma, vertical growth
+ Nodular melanoma
+ Nevoid melanoma
+ Acrolentiginous and mucosal melanoma
+ Melanoma ex nevo
+ Balloon cell melanoma
+ Small cell melanoma
+ Desmoplastic melanoma
+ Melanoma developing within congenital nevus, child, 6 years
+ Melanoma of the conjunctiva
+ Melanoma metastases
+ Merkel cell carcinoma
+ Cysts of the skin and subcutis
+ Cysts with epithelial lining
+ Cysts with lining of epidermal type
+ Epidermal (infundibular) cyst
+ Epidermal cyst combined with HPV infection
+ Epidermal verrucous cyst combined with HPV infection
+ Epidermal inclusion cyst
+ Hair matrix cyst
+ Epidermal proliferating cyst
+ Trichilemmal cyst
+ Proliferating trichilemmal cyst
+ Dermoid cyst
+ Cystic teratoma
+ Cystic teratoma of the ovary
+ Pigmented follicular cyst
+ Steatocystoma multiplex
+ Skin keratocyst
+ Vellus hair cyst
+ Cystis colli mediana, thyreoglossal duct cyst
+ Giant comedo
+ Milium
+ Preauricular sinus (pit)
+ Thymic cyst
+ Bronchogenic cyst
+ Branchial cleft cyst
+ Cutaneous ciliated cyst of the lower limbs
+ Vulval mucinous and ciliated cyst
+ Gartner's duct cyst
+ Endometriosis
+ Median raphe cyst
+ Hidrocystoma
+ Eccrine hidrocystoma
+ Apocrinne hidrocystoma (and its papillary variant)
+ Apocrine cystadenoma (papillary)
+ Non-epithelial cysts, pseudocysts
+ Ganglion, synovial cyst
+ Digital mucous cyst
+ Mucocele
+ Pilonidal sinus
+ Pseudocyst of the auricle
+ Parasitic cyst
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Syphilis
+ Gonorrhea
+ Trichomonas vaginalis
+ Pathology of the foreskin, phimosis, balanitis
+ Balanitis
+ Balanitis plasmocellularis Zoon
+ Balanitis circinata
+ Phimosis, paraphimosis, frenulum breve and other lesions of the penis
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
+ Collection of histological slides of dr. Ram Chandra Adhikari
T cell receptor gamma/delta chain positive cutaneous lymphoma
Introduction

Most peripheral T cell lymphomas express the clone specific alpha/beta heterodimer. T lymphocytes bearing the gamma/delta heterodimer usually consist of less than 5% of the peripheral blood lymphocytes and show an increase in distinct infectious conditions like leprosy. About 3% of CDTL arise form the gamma/delta positive clone of lymphocytes, showing primary or preferential homing into the skin.

Clinical signs
  • simulate MF or pagetoid reticulosis (cases of so called generalized pagetoid reticulosis of Ketron Goodman belong to this category)
  • clinical course is highly progressive in most cases, but may also be slowly progressive over many years
  • subcutaneous, pagetoid, erythrodermic and tumorous forms exist
  • subcutaneuous form resembles panniculitis, but the clinical course is more aggresive than that of subcutaneous panniculitis-like lymphoma of alpha/beta cell type
Histology

The infiltrate is localized within the upper dermis or epidermis (sometimes epidermotropic: pagetoid type) or in the subcutaneous tissue (panniculitic type); consists of the medium-sized to large pleomorphic cells with abundant cytoplasm. Tissue necroses and vascular invasion are common.

Immunophenotype and genetic features:

  • CD3+, CD43+, CD45RO+, CD4+/-, CD8+/-, CD56+/-, CD5-, CD30-, CD15-
  • TIA-1, granzyme B, granzyme M and perforin are usually positive
  • hallmark: positivity for the gamma/delta TCR (and lack betaF1 epitope of the alpha/beta receptor)

Subcutaneous panniculitis-like lymphoma gamma/delta (6000)

Pictures

Subcutaneous panniculitis-like lymphoma gamma/delta: Subcutaneous panniculitis-like lymphoma gamma/delta, HE 20x (4700) Subcutaneous panniculitis-like lymphoma, HE 20x (6000)