Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Spindle cell hemangioma
Clinical signs
  • age: young adults
  • location: distal extremities (esp. hand)
  • often near a larger veins
  • tumorous vascular spaces contain thrombi, often calcified
  • sometimes associated with Maffucci's and Klippel-Trénaunay syndromes
  • solitary or multiple papule
  • often reccurrs after surgery
  • benign tumor
Histology

Cavernous vessels with thin walls, containing thrombi. Between these spaces there are areas of spindle cells and fibrocytes (vimentin positive). The spindle cells are positive for ASMA (marker for pericytes) and mostly negative for endothelial markers (CD31, CD34). Spindle cell areas contain polygonal, epithelioid endothelial cells (CD31 and CD34 positive) with vacuolated cytoplasm. The vacuoles are sometimes large, so that these cells may resemble fat.

Vřetenobuněčný hemangiom (5150)