Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Perforating collagenosis
Clinical signs
  • rare skin disease
  • transepidermal elimination of collagen
  • types:
    • inherited
    • acquired (patients with diabetes or chronic renal failure on dialysis and some other diseases)
  • intense pruritus
  • papules, healing with scarring
  • location: extensor parts of the limbs
Pictures

Reactive perforating collagenosis (histology see bellow, 6330, 6329): Collagenosis perforans, Clinical picture (13322) Collagenosis perforans, Clinical picture (13321)

Histology

Focus of thinned epidermis with transepidermal elimination of collagen fibres and dermal inflammation. Sometimes the defect is complete and collagen fibres can be seen in necrotic tissue covered by parakeratotic plug.