Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
×
+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Paraneoplastic pemphigus
Etiology, pathogenesis

May accompany malignant neoplastic process (lymphoma, leukemia and others).

Clinical signs
  • the course depends on the accompanied malignant disease, prognosis is unfavourable
  • macules, papules, vesicles; often widespread
  • lichenoid papules
  • affects mucous membranes with erosions, including bronchial mucosa
  • respiratory mucosa can be affected as well
Histology

Superficial perivascular lymphocytic infiltrate, vacuolar degeneration of the basal layer, slight spongiosis, suprabasal acantholysis, necrotic keratinocytes, focal parakeratosis, excoriation (mucosa).