Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Ochronosis
Clinical signs
  • endogenous ochronosis (alcaptonuria)
    • autosomal recessive metabolic disease
    • generalized deposits of homogentisic acid in soft tissues (esp. cartilage, joints, sclerae)
    • lasts years
  • exogenous ochronosis
    • after topical application of hydroquinone (bleaching)
    • bluish or black hyperpigmentations, papules, milia
    • limited to exposed areas
Histology

Deposits of yellow brown pigment within the dermis, esp. within the collagen; small granular deposits can be found in endothelium, histiocytes and sweat glands.

Brown pigmentation of cartilage and connective tissue.