Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Eczematized melanocytic nevus
Clinical signs
  • common nevi develop erythematous reaction
Histology

Common nevus with inflammatory infiltrate with eosinophils.

Case study
Meyerson's nevus
MUDr. Hana Jedličková, PhD.
Introduction

This type of nevus was described in 1971 by L. B. Meyerson (A Peculiar Papulosquamous Eruption Involving Pigmented Nevi). His patients were two young men with inflammatory papulosquamous changes of their melanocytic nevi. The inflammation healed after several months, leaving the nevi intact.

Histologically a melanocytic nevus is found with changes as parakeratosis, focal spongiosis, acanthosis and lymphocytic perivascular infiltrate with eosinophils.

The etiology is unknown, Koebner phenomenon in pityriasis rosea was suggested, and on the other hand no association with atopy has been found. An upregulation of ICAM 1 was described.

The lesions can be solitary or multiple. The condition is more common in young men.

Meyerson phenomenon can occur also in seborrhoeic keratosis, dermatofibroma, basal cell carcinoma and squamous cell carcinoma.

Progression into halo nevus was described.

History

29-year-old man had a history of returning inflammation of melanocytic nevi on his left upper extremity for approx. 6 years. He reported infrequent itching of other nevi on the trunk. He was otherwise healthy.

The inflammation always healed after several weeks; only topical corticosteroids were used.

One lesion was excised for histological examination.

Clinical signs

The patient was phototype III. On his left arm he had a light brown nevus with an eczematous circle of 1 cm in diameter with yellow crusts and oozing. Similar but not so prominent changes were found in one other nevus. On the trunk he had two halo nevi and several pigmented nevi, some of them with red brown color.

Meyerson's nevus (6155)

Pictures

Meyerson's nevus: Meyerson nevus, Clinical picture (6155)

Histology

In the centre of the lesion is a small compound nevus. Epidermis shows acanthosis and spongiosis extending significantly the nevus. In the spongiotic vesicles there are many lymphocytes and some eosinophils. Superficial inflammatory lymphohistiocytic perivascular infiltrate has an admixture of eosinophils.

Meyerson's nevus (4148)

Pictures

Eczematized melanocytic nevus of Meyerson: Eczematized nevus, HE 40x (4148)