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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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ExpSys: non-tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Marginal zone lymphoma
Introduction

Monocytoid B cell lymphoma. Reffered by some authors as mucosa associated lymphoid tissue lymphoma (MALT) or skin associated lymphoid tissue lymphoma (SALT). Association with Borrelia burgdorferi has been suggested.

Clinical signs
  • red-brown papules, plaques or nodules
  • tendency to recurrences, but excellent long term prognosis
Histology

Nodular or diffuse infiltrates in the dermis and subcutis without involvement of the epidermis. Sometimes reactive follicles are present within the infiltrate.

Cytology: small to medium sized cells with convoluted “monocytoid” nuclei and a pale cytoplasm resembling centrocytes. Additional cell types such as plasma cells, histiocytes and eosinophils are present.

Immunophenotype and genetic features:

  • Tumor cells: CD20+, CD79a+, but CD5- a CD10-
  • Typical feature: granular cytoplasmic staining pattern using the Ki-M1p antibody reacting with monocytoid B cells
  • expression of Ig light chains only in 50% of cases
  • Genotype: clonal rearrangement of Ig heavy chain gene in some cases

Marginal zone lymphoma (2498)

Marginal zone lymphoma (2498)

Marginal zone lymphoma (4564)

Marginal zone lymphoma, bcl2 (4558)

Marginal zone lymphoma, bcl6 (4559)

Marginal zone lymphoma, CD21 (4560)

Pictures

Marginal zone lymphoma: Marginal zone lymphoma, HE 40x (2231) Marginal zone lymphoma, HE 100x (2498) Marginal zone lymphoma, HE 100x (2548)

Another case: Marginal zone lymphoma, HE 40x (2562) Marginal zone lymphoma, HE 100x (2499)

Another case: Marginal zone lymphoma, HE 20x (2425) Marginal zone lymphoma, HE 40x (2426) Marginal zone lymphoma, HE 100x (2512)

Another case: Marginal zone lymphoma (MZL), HE 20x (4556) Marginal zone lymphoma (MZL), bcl2 20x (4551) Marginal zone lymphoma (MZL), bcl2 20x (4552) Marginal zone lymphoma (MZL), bcl6 20x (4553) Marginal zone lymphoma (MZL), bcl6 20x (4554) Marginal zone lymphoma (MZL), CD21 20x (4555)

Another case: Marginal zone lymphoma (MZL), HE 20x (4564) Marginal zone lymphoma (MZL), bcl2 20x (4558) Marginal zone lymphoma (MZL), bcl6 20x (4559) Marginal zone lymphoma (MZL), CD79a 20x (4562) Marginal zone lymphoma (MZL), CD21 20x (4560)

Another case: Marginal zone lymphoma (MZL), HE 20x (4864)

Another case: Marginal zone lymphoma (MZL), HE 20x (4865)

Another case: Marginal zone lymphoma (MZL), HE 20x (4866)

Another case: Marginal zone lymphoma (MZL), HE 20x (4867)

Another case: Marginal zone lymphoma (MZL), HE 20x (5316)

Another case: MALT lymphoma, skin, HE 60x (74588) MALT lymphoma, skin, CD20 60x (10047) MALT lymphoma, skin, bcl2 40x (10042) MALT lymphoma, skin, bcl6 40x (10043) MALT lymphoma, skin, CD10 40x (10044) MALT lymphoma, skin, CD5 40x (10045) MALT lymphoma, skin, CD3 60x (10048) MALT lymphoma, skin, Ki67 40x (10046)

Marginal zone lymphoma destroying hair follicles: Marginal zone lymphoma (MZL), HE 40x (6046) Marginal zone lymphoma (MZL), HE 40x (6047) Marginal zone lymphoma (MZL), CD20 40x (6048) Marginal zone lymphoma, CD3 40x (6050) Marginal zone lymphoma (MZL), bcl2 40x (6044) Marginal zone lymphoma (MZL), bcl6 40x (6045)

Marginal zone lymphoma: Marginal zone lymphoma (MZL), HE 60x (12983)

Marginal zone lymphoma, immunocytoma variant
Marginal zone lymphoma, plasmocytoma variant