Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Giant melanocytic nevus
Clinical signs
  • inborn melanocytic nevus
  • color: dark brown
  • size: large (many centimeters, may cover large areas of the body)
  • usually with fine hairs
  • benign, but melanoma may develop (even multilocular)

Giant melanocytic nevus (3152)

Pictures

Giant melanocytic nevus: Melanocytic nevus, giant, congenital, Clinical picture (3152)

Further examples of congenital nevi:

Histology

Melanocytic nevus (compound or intradermal) composed of regular melanocytes. The melanocytes reach deep into the dermis, spread along the adnexa. Deep parts may show neuroid differentiation. Areas of a blue nevus may be present as well.

Cellular nodules of low mitotic activity may develop. Some of them may turn malignant (high atypia, high mitotic activity, necrosis).

Giant melanocytic nevus (3486)

Pictures

Giant melanocytic nevus: Melanocytic nevus, giant, congenital, HE 40x (2368)

Another case: Melanocytic nevus, giant, congenital, HE 20x (2558)

Another case with small nodule with regression: Melanocytic nevus, giant, congenital, HE 20x (3486) Melanocytic nevus, giant, congenital, HE 40x (3488) Melanocytic nevus, giant, congenital, Ki67 20x (3487)

Congenital melanocytic nevus with clonal proliferation: Congenital nevus with clonal melanocytic proliferation, HE 20x (4197)

Congenital melanocytic nevus with clonal proliferation: Congenital clonal melanocytic nevus, HE 40x (12712)

Congenital melanocytic nevus, child 5 months: Congenital melanocytic nevus, child 5 months, HE 60x (14288) Congenital melanocytic nevus, child 5 months, HE 60x (14289)

Melanosis, remnats of giant congenital melanocytic nevus: Melanosis, remnants of giant melanocytic nevus, HE 60x (10477)