Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Merkel cell carcinoma
Clinical signs
  • location: most often the extremities or the head
  • solitary tumorous nodule, usually no ulceration
  • malignant behaviour, infiltrative growth, metastases
Histology

Sheets of small, round cells with narrow cytoplasm; high mitotic activity; inconspicuous nucleoli; positivity for NSE, chromogranin, CD57; paranuclear positivity for cytokeratin 20.

Merkel cell carcinoma, HE (1445)

Merkel cell carcinoma, HE (13955)

Merkel cell carcinoma, CD20 (13954)

Pictures

Merkel cell carcinoma: Merkel cell carcinoma, HE 10x (1443) Merkel cell carcinoma, HE 20x (1444) Merkel cell carcinoma, HE 40x (1445) Merkel cell carcinoma, CK20 20x (1793) Merkel cell carcinoma, CK20 100x (1792)

Another case: Merkel cell carcinoma, HE 40x (2003) Merkel cell carcinoma, HE 40x (2004)

Another case, trabecular tumor: Merkel cell carcinoma, eyelid, HE 10x (2530) Merkel cell carcinoma, eyelid, HE 40x (2532) Merkel cell carcinoma, eyelid, HE 100x (2531) Merkel cell carcinoma, CK20 100x (2560) Merkel cell carcinoma, chromogranin 40x (2561) Merkel cell carcinoma, AE13 40x (2547)

Another case: Merkel cell carcinoma, HE 20x (4814) Merkel cell carcinoma, HE 20x (4536) Merkel cell carcinoma, CK20 20x (4813)

Another case: Merkel cell carcinoma, HE 20x (5363)

Another case: Merkel cell carcinoma, HE 20x (6204) Merkel cell carcinoma, HE 40x (6219)

Another case: Merkel cell carcinoma, HE 40x (6451) Merkel cell carcinoma, NSE 40x (6444) Merkel cell carcinoma, CK20 40x (6443)

Another case: Merkel cell carcinoma, HE 60x (10053) Merkel cell carcinoma, CK20 60x (10052)

Another case, strong CD20 positivity: Merkel cell carcinoma, HE 60x (13955) Merkel cell carcinoma, CK20 60x (13954)

Another case: Merkel cell carcinoma, HE 40x (12915) Merkel cell carcinoma, HE 40x (12916)

Combination of Merkel cell carcinoma and squamous cell carcinoma: Merkel cell carcinoma and squamous cell carcinoma, HE 40x (13303) Merkel cell carcinoma and squamous cell carcinoma, HE 40x (13304) Merkel cell carcinoma and squamous cell carcinoma, CK20 40x (13302)