Pathology
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Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
Index
Contents
Authors
ExpSys: non-tumors
ExpSys: tumors
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Desmoplastic melanoma
Clinical signs
  • plaque or nodule
  • about half of the cases are pigmented
  • location: sun exposed areas, namely head, neck (ear, lip, nose)
Histology

Spindle shaped malignant melanocytes, often unpigmented. Sometimes the cells form fascicles. Atypia of the cells is mild or moderate. The tumor usually reaches deep into the dermis. There is patchy lymphocytic infiltrate within the tumor. Perineural involvement is common.

Immunoprofile: S100 variable, often weak; Melan A usually negative, vimentin positive.

Desmoplastic melanoma (4810)

Desmoplastic melanoma (4810)

Pictures

Desmoplastic melanoma, tumor in scanning magnification and details: Malignant melanoma, desmoplastic, HE 20x (4454) Malignant melanoma, desmoplastic, HE 20x (4455) Malignant melanoma, desmoplastic, HE 20x (4456) Malignant melanoma, desmoplastic; margins, HE 20x (4457)

Desmoplastic melanoma: Malignant melanoma, desmoplastic, HE 20x (4810) Malignant melanoma, desmoplastic, HE 20x (4809)

Desmoplastic melanoma: Malignant melanoma, desmoplastic, HE 20x (5362) Malignant melanoma, desmoplastic, HE 20x (5361)

Desmoplastic melanoma: Desmoplastic melanoma, HE 40x (10026) Desmoplastic melanoma, S100 40x (10027)

Desmoplastic melanoma: Malignant melanoma, desmoplastic, Melan A 20x (14565) Malignant melanoma, desmoplastic, S100 20x (14566)

Desmoplastic melanoma: Malignant melanoma, desmoplastic, HE 60x (14664) Malignant melanoma, desmoplastic, HE 60x (14665) Malignant melanoma, desmoplastic, S100 20x (14663) Malignant melanoma, desmoplastic, HMB45 20x (14659) Malignant melanoma, desmoplastic, HMB45 20x (14660) Malignant melanoma, desmoplastic, Melan A 20x (14661) Malignant melanoma, desmoplastic, Melan A 20x (14662) Malignant melanoma, desmoplastic, CD68 20x (14658) Malignant melanoma, desmoplastic, AE13 20x (14657)