Pathology
Images
Atlas of dermatopathology
Josef Feit, Hana Jedličková, Günter Burg, Luděk Matyska, Spasoje Radovanovic et al.
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+ Introduction
+ Literature
+ Support
+ Skin biopsy
+ Non-tumorous skin diseases
+ Skin tumors
+ Cysts of the skin and subcutis
+ Soft tissue lesions
+ Some lesions of the oral cavity
+ Dermatovenerology
+ Collection of histological slides by prof. Günter Burg
+ Collection of histological slides by prof. Werner Kempf
+ Collection of histological slides of dr. Ram Chandra Adhikari
Toxic epidermal necrolysis of Lyell
Clinical signs
  • the most severe drug eruption, TEN can affect up to 100% of the skin surface
  • multiform lesions, blisters, the epidermis peels off, leaving denuded areas
  • erosions and hemorrhagic crusts on the mucous membranes
  • Nikolsky's sign is positive
  • malaise, fever, loss of fluids, danger of infectious complications
  • life threatening disease
  • infectious etiology in some cases (staphyloccocus)
Histology

Necrosis of the whole epidermis, subepidermal bulla, dermo-epidermal separation.